Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995809259> ?p ?o ?g. }
- W1995809259 endingPage "9256" @default.
- W1995809259 startingPage "9246" @default.
- W1995809259 abstract "The 57-residue small hydrophilic endoplasmic reticulum-associated protein (SHERP) shows highly specific, stage-regulated expression in the non-replicative vector-transmitted stages of the kinetoplastid parasite, Leishmania major, the causative agent of human cutaneous leishmaniasis. Previous studies have demonstrated that SHERP localizes as a peripheral membrane protein on the cytosolic face of the endoplasmic reticulum and on outer mitochondrial membranes, whereas its high copy number suggests a critical function in vivo. However, the absence of defined domains or identifiable orthologues, together with lack of a clear phenotype in transgenic parasites lacking SHERP, has limited functional understanding of this protein. Here, we use a combination of biophysical and biochemical methods to demonstrate that SHERP can be induced to adopt a globular fold in the presence of anionic lipids or SDS. Cross-linking and binding studies suggest that SHERP has the potential to form a complex with the vacuolar type H(+)-ATPase. Taken together, these results suggest that SHERP may function in modulating cellular processes related to membrane organization and/or acidification during vector transmission of infective Leishmania." @default.
- W1995809259 created "2016-06-24" @default.
- W1995809259 creator A5006040025 @default.
- W1995809259 creator A5014092272 @default.
- W1995809259 creator A5018579799 @default.
- W1995809259 creator A5023673042 @default.
- W1995809259 creator A5054862204 @default.
- W1995809259 creator A5056994790 @default.
- W1995809259 creator A5064737704 @default.
- W1995809259 creator A5081131186 @default.
- W1995809259 creator A5084813588 @default.
- W1995809259 date "2011-03-01" @default.
- W1995809259 modified "2023-10-01" @default.
- W1995809259 title "Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces" @default.
- W1995809259 cites W1517181973 @default.
- W1995809259 cites W1554885948 @default.
- W1995809259 cites W1555734844 @default.
- W1995809259 cites W1589295940 @default.
- W1995809259 cites W1598788587 @default.
- W1995809259 cites W1844422703 @default.
- W1995809259 cites W1958092593 @default.
- W1995809259 cites W1966314292 @default.
- W1995809259 cites W1974326515 @default.
- W1995809259 cites W1977433737 @default.
- W1995809259 cites W1984960998 @default.
- W1995809259 cites W1996512905 @default.
- W1995809259 cites W1998731304 @default.
- W1995809259 cites W2001819758 @default.
- W1995809259 cites W2002768329 @default.
- W1995809259 cites W2004182243 @default.
- W1995809259 cites W2004242436 @default.
- W1995809259 cites W2005030916 @default.
- W1995809259 cites W2005097296 @default.
- W1995809259 cites W2007630314 @default.
- W1995809259 cites W2014870946 @default.
- W1995809259 cites W2017905166 @default.
- W1995809259 cites W2018633688 @default.
- W1995809259 cites W2022428567 @default.
- W1995809259 cites W2026727321 @default.
- W1995809259 cites W2027109238 @default.
- W1995809259 cites W2027824759 @default.
- W1995809259 cites W2027868805 @default.
- W1995809259 cites W2028103003 @default.
- W1995809259 cites W2030776726 @default.
- W1995809259 cites W2037584614 @default.
- W1995809259 cites W2040615674 @default.
- W1995809259 cites W2043358632 @default.
- W1995809259 cites W2046144222 @default.
- W1995809259 cites W2052035193 @default.
- W1995809259 cites W2053202752 @default.
- W1995809259 cites W2054737424 @default.
- W1995809259 cites W2054983719 @default.
- W1995809259 cites W2060178110 @default.
- W1995809259 cites W2061369703 @default.
- W1995809259 cites W2061720596 @default.
- W1995809259 cites W2062562477 @default.
- W1995809259 cites W2063858038 @default.
- W1995809259 cites W2067143036 @default.
- W1995809259 cites W2068602144 @default.
- W1995809259 cites W2070362118 @default.
- W1995809259 cites W2071758457 @default.
- W1995809259 cites W2072650185 @default.
- W1995809259 cites W2075681541 @default.
- W1995809259 cites W2077436141 @default.
- W1995809259 cites W2083483750 @default.
- W1995809259 cites W2092359177 @default.
- W1995809259 cites W2096142106 @default.
- W1995809259 cites W2103080864 @default.
- W1995809259 cites W2118830268 @default.
- W1995809259 cites W2121990753 @default.
- W1995809259 cites W2122242788 @default.
- W1995809259 cites W2123540590 @default.
- W1995809259 cites W2123905860 @default.
- W1995809259 cites W2124286005 @default.
- W1995809259 cites W2125103697 @default.
- W1995809259 cites W2130323165 @default.
- W1995809259 cites W2132694729 @default.
- W1995809259 cites W2134057677 @default.
- W1995809259 cites W2137022236 @default.
- W1995809259 cites W2137745009 @default.
- W1995809259 cites W2138375082 @default.
- W1995809259 cites W2139406994 @default.
- W1995809259 cites W2140260269 @default.
- W1995809259 cites W2154080115 @default.
- W1995809259 cites W2155477793 @default.
- W1995809259 cites W2168799765 @default.
- W1995809259 cites W2169818027 @default.
- W1995809259 cites W2170302951 @default.
- W1995809259 cites W2170956456 @default.
- W1995809259 cites W4230530740 @default.
- W1995809259 cites W4253116674 @default.
- W1995809259 cites W4294618397 @default.
- W1995809259 doi "https://doi.org/10.1074/jbc.m110.130427" @default.
- W1995809259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3059043" @default.
- W1995809259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21106528" @default.
- W1995809259 hasPublicationYear "2011" @default.
- W1995809259 type Work @default.
- W1995809259 sameAs 1995809259 @default.