FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995821706> ?p ?o ?g. }

• W1995821706 endingPage "1219" @default.
• W1995821706 startingPage "1213" @default.
• W1995821706 abstract "Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined.Theophylline, a xanthine bronchodilator was used to model controlled release owing to its narrow therapeutic index. Microspheres were prepared using different ratios of dual surfactant in an emulsion-solvent evaporation process. Drug loading, encapsulation efficiency, particle size distribution, and geometric mean diameters were evaluated. Drug release was evaluated using several kinetic models including zero and first order, Higuchi square root, and Hixson-Crowell.Microspheres presented as mostly spherical particles and diffusional drug release was affected by microsphere construction. For this novel, dual surfactant system the microsphere matrix is a hydrophobic polymer and the release rate may be modulated with variation in ratio of dual surfactants. Dissolution data followed the Higuchi model and supports the formation of a monolithic microsphere matrix that releases theophylline by Fickian diffusion.Dual surfactants for preparation of microspheres are an inadequately studied research area that offers another means to modulate particle size and drug release. For the current study microspheres prepared with surfactant ratios of Span 65: Tween 40 between 3:1 and 2:1 provided the best control of size and drug release." @default.
• W1995821706 created "2016-06-24" @default.
• W1995821706 creator A5012755060 @default.
• W1995821706 creator A5027479823 @default.
• W1995821706 creator A5042368086 @default.
• W1995821706 creator A5042730212 @default.
• W1995821706 creator A5048088398 @default.
• W1995821706 creator A5052746903 @default.
• W1995821706 creator A5065551033 @default.
• W1995821706 creator A5071479297 @default.
• W1995821706 date "2011-10-12" @default.
• W1995821706 modified "2023-10-14" @default.
• W1995821706 title "Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres: effect of different dual surfactant ratios" @default.
• W1995821706 cites W1580138291 @default.
• W1995821706 cites W1966882243 @default.
• W1995821706 cites W1973438830 @default.
• W1995821706 cites W1978971887 @default.
• W1995821706 cites W1980535921 @default.
• W1995821706 cites W1986155585 @default.
• W1995821706 cites W1987576995 @default.
• W1995821706 cites W1988468764 @default.
• W1995821706 cites W1989816837 @default.
• W1995821706 cites W1994418823 @default.
• W1995821706 cites W1994621872 @default.
• W1995821706 cites W2005488258 @default.
• W1995821706 cites W2006369077 @default.
• W1995821706 cites W2009841111 @default.
• W1995821706 cites W2011192062 @default.
• W1995821706 cites W2022123157 @default.
• W1995821706 cites W2031830981 @default.
• W1995821706 cites W2033387589 @default.
• W1995821706 cites W2071341284 @default.
• W1995821706 cites W2086130473 @default.
• W1995821706 cites W2091148013 @default.
• W1995821706 cites W2091317812 @default.
• W1995821706 cites W2094743004 @default.
• W1995821706 cites W2106461166 @default.
• W1995821706 cites W2115439624 @default.
• W1995821706 cites W2121766941 @default.
• W1995821706 cites W2122007461 @default.
• W1995821706 cites W2126951636 @default.
• W1995821706 cites W2137901709 @default.
• W1995821706 cites W2152938106 @default.
• W1995821706 cites W2162890305 @default.
• W1995821706 cites W2170714542 @default.
• W1995821706 cites W270606568 @default.
• W1995821706 cites W321881051 @default.
• W1995821706 cites W4230354264 @default.
• W1995821706 cites W4249250162 @default.
• W1995821706 cites W2011699099 @default.
• W1995821706 doi "https://doi.org/10.3109/10837450.2011.620969" @default.
• W1995821706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21991996" @default.
• W1995821706 hasPublicationYear "2011" @default.
• W1995821706 type Work @default.
• W1995821706 sameAs 1995821706 @default.
• W1995821706 citedByCount "11" @default.
• W1995821706 countsByYear W19958217062012 @default.
• W1995821706 countsByYear W19958217062013 @default.
• W1995821706 countsByYear W19958217062014 @default.
• W1995821706 countsByYear W19958217062016 @default.
• W1995821706 countsByYear W19958217062017 @default.
• W1995821706 countsByYear W19958217062020 @default.
• W1995821706 countsByYear W19958217062023 @default.
• W1995821706 crossrefType "journal-article" @default.
• W1995821706 hasAuthorship W1995821706A5012755060 @default.
• W1995821706 hasAuthorship W1995821706A5027479823 @default.
• W1995821706 hasAuthorship W1995821706A5042368086 @default.
• W1995821706 hasAuthorship W1995821706A5042730212 @default.
• W1995821706 hasAuthorship W1995821706A5048088398 @default.
• W1995821706 hasAuthorship W1995821706A5052746903 @default.
• W1995821706 hasAuthorship W1995821706A5065551033 @default.
• W1995821706 hasAuthorship W1995821706A5071479297 @default.
• W1995821706 hasConcept C127413603 @default.
• W1995821706 hasConcept C13245373 @default.
• W1995821706 hasConcept C147789679 @default.
• W1995821706 hasConcept C155574463 @default.
• W1995821706 hasConcept C178790620 @default.
• W1995821706 hasConcept C185592680 @default.
• W1995821706 hasConcept C187530423 @default.
• W1995821706 hasConcept C192562407 @default.
• W1995821706 hasConcept C2776035855 @default.
• W1995821706 hasConcept C2778095195 @default.
• W1995821706 hasConcept C2778123984 @default.
• W1995821706 hasConcept C2779820397 @default.
• W1995821706 hasConcept C42360764 @default.
• W1995821706 hasConcept C43617362 @default.
• W1995821706 hasConcept C521977710 @default.
• W1995821706 hasConcept C55493867 @default.
• W1995821706 hasConcept C58226133 @default.
• W1995821706 hasConcept C71924100 @default.
• W1995821706 hasConcept C77281830 @default.
• W1995821706 hasConcept C88380143 @default.
• W1995821706 hasConcept C98274493 @default.
• W1995821706 hasConceptScore W1995821706C127413603 @default.
• W1995821706 hasConceptScore W1995821706C13245373 @default.
• W1995821706 hasConceptScore W1995821706C147789679 @default.
• W1995821706 hasConceptScore W1995821706C155574463 @default.
• W1995821706 hasConceptScore W1995821706C178790620 @default.

• next