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- W1995838928 abstract "Thirty one derivatives were prepared from the natural alkaloids haemanthamine (1), haemanthidine (2) and 11-hydroxyvittatine (3). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and some structure–activity relationships were outlined. For haemanthamine derivatives having a methoxy group at C-3, the presence of a free hydroxyl group at C-11 is important for the activity. The double bond at C-1–C-2 plays also an important role to achieve good inhibitory activity. Compound 35 with two nicotinate groups at C-3 and at C-11 was the most active compound with a IC50 = 0.8 ± 0.06 μM." @default.
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- W1995838928 date "2012-09-01" @default.
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- W1995838928 title "Synthesis and antimalarial activity of new haemanthamine-type derivatives" @default.
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- W1995838928 doi "https://doi.org/10.1016/j.bmc.2012.07.036" @default.
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