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- W1995842016 abstract "Ciliary compartmentalization plays pivotal roles in ciliogenesis and in various signaling pathways. Here we describe a structure at the ciliary base that appears to have all the features required for compartmentalization and which we thus call the ciliary partitioning system (CPS). This complex consists of the terminal plate, which serves as a cytosolic ciliary pore complex (CPC), and a membrane region well suited to serve as a diffusion barrier. The CPC is a plate-shaped structure containing nine pores through which the microtubule doublets of the basal body pass. Each pore expands from the doublet B-tubule into an opening well suited for the passage of intraflagellar transport particles. The membrane diffusion barrier encompasses an extended region of detergent-resistant periciliary membrane (ciliary pocket) and a ring complex that connects the CPC to the membrane. Proteomics analysis shows involvement of the ciliary pocket in vesicle trafficking, suggesting that this region plays an active role in membrane transport. The CPC and the ring together form a complete partition defining the ciliary boundary." @default.
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- W1995842016 date "2013-02-01" @default.
- W1995842016 modified "2023-10-02" @default.
- W1995842016 title "Architectural Insights into a Ciliary Partition" @default.
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- W1995842016 doi "https://doi.org/10.1016/j.cub.2013.01.029" @default.
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