FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995853487> ?p ?o ?g. }

• W1995853487 endingPage "2643" @default.
• W1995853487 startingPage "2635" @default.
• W1995853487 abstract "We have identified and characterized a mouse brain calcitonin receptor (CTR) complementary DNA (cDNA). This cDNA encodes a receptor protein that, after expression, has high affinity binding for salmon calcitonin (Kd approximately, 12.5 nM) and is coupled to adenylate cyclase. The binding affinity of this expressed receptor for salmon calcitonin is lower than that described for the previously cloned porcine renal and human ovarian CTRs, but is similar to that of the recently described rat brain CTR, designated the C1b form of the receptor. Analysis of the deduced structure of the mouse brain CTR reveals that it is highly related to the other CTR cDNAs that belong to a distinct family of G-protein-coupled receptors with seven transmembrane-spanning domains. The major structural feature that distinguishes the mouse cDNA clone from the other CTRs is the presence of a consecutive 111-basepair nucleotide sequence that encodes a 37-amino acid sequence which is predicted to localize to the first extracellular loop between the second and third transmembrane-spanning domains. We have mapped the CTR gene in the mouse to the proximal region of chromosome 6, which is homologous to the 7q region of human chromosome 7; only a single CTR gene was identified. Preliminary analysis of the mouse CTR gene reveals that it is complex, consisting of multiple exons separated by lengthy introns that would allow for splice variants consistent with the existence of multiple CTR isoforms predicted from the CTR cDNA clones. The differential cellular and tissue distribution of these functionally distinct CTR isoforms provides the molecular basis for the previously reported widespread distribution and functional heterogeneity of the CTR." @default.
• W1995853487 created "2016-06-24" @default.
• W1995853487 creator A5014542948 @default.
• W1995853487 creator A5017131511 @default.
• W1995853487 creator A5030034684 @default.
• W1995853487 creator A5064614154 @default.
• W1995853487 creator A5068784832 @default.
• W1995853487 creator A5080984126 @default.
• W1995853487 creator A5086653323 @default.
• W1995853487 creator A5087131846 @default.
• W1995853487 creator A5087583176 @default.
• W1995853487 date "1994-12-01" @default.
• W1995853487 modified "2023-10-11" @default.
• W1995853487 title "Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene." @default.
• W1995853487 cites W1602599837 @default.
• W1995853487 cites W1630546024 @default.
• W1995853487 cites W1657789828 @default.
• W1995853487 cites W1955225173 @default.
• W1995853487 cites W1966819735 @default.
• W1995853487 cites W1968093456 @default.
• W1995853487 cites W1978634747 @default.
• W1995853487 cites W1978817835 @default.
• W1995853487 cites W2009310436 @default.
• W1995853487 cites W2040067193 @default.
• W1995853487 cites W2043355910 @default.
• W1995853487 cites W2043610823 @default.
• W1995853487 cites W2045543114 @default.
• W1995853487 cites W2049183086 @default.
• W1995853487 cites W2051563711 @default.
• W1995853487 cites W2078739782 @default.
• W1995853487 cites W2084376887 @default.
• W1995853487 cites W2087997490 @default.
• W1995853487 cites W2116949924 @default.
• W1995853487 cites W2130572726 @default.
• W1995853487 cites W2138879032 @default.
• W1995853487 cites W2160088320 @default.
• W1995853487 cites W2302834777 @default.
• W1995853487 cites W2396394505 @default.
• W1995853487 cites W2468883625 @default.
• W1995853487 cites W89403364 @default.
• W1995853487 cites W2562379793 @default.
• W1995853487 doi "https://doi.org/10.1210/endo.135.6.7988453" @default.
• W1995853487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7988453" @default.
• W1995853487 hasPublicationYear "1994" @default.
• W1995853487 type Work @default.
• W1995853487 sameAs 1995853487 @default.
• W1995853487 citedByCount "44" @default.
• W1995853487 countsByYear W19958534872015 @default.
• W1995853487 countsByYear W19958534872017 @default.
• W1995853487 countsByYear W19958534872020 @default.
• W1995853487 crossrefType "journal-article" @default.
• W1995853487 hasAuthorship W1995853487A5014542948 @default.
• W1995853487 hasAuthorship W1995853487A5017131511 @default.
• W1995853487 hasAuthorship W1995853487A5030034684 @default.
• W1995853487 hasAuthorship W1995853487A5064614154 @default.
• W1995853487 hasAuthorship W1995853487A5068784832 @default.
• W1995853487 hasAuthorship W1995853487A5080984126 @default.
• W1995853487 hasAuthorship W1995853487A5086653323 @default.
• W1995853487 hasAuthorship W1995853487A5087131846 @default.
• W1995853487 hasAuthorship W1995853487A5087583176 @default.
• W1995853487 hasConcept C104317684 @default.
• W1995853487 hasConcept C118303440 @default.
• W1995853487 hasConcept C118892022 @default.
• W1995853487 hasConcept C134018914 @default.
• W1995853487 hasConcept C153911025 @default.
• W1995853487 hasConcept C163170386 @default.
• W1995853487 hasConcept C167625842 @default.
• W1995853487 hasConcept C170493617 @default.
• W1995853487 hasConcept C17971392 @default.
• W1995853487 hasConcept C187882448 @default.
• W1995853487 hasConcept C189482833 @default.
• W1995853487 hasConcept C2779627488 @default.
• W1995853487 hasConcept C36823959 @default.
• W1995853487 hasConcept C53345823 @default.
• W1995853487 hasConcept C54355233 @default.
• W1995853487 hasConcept C86803240 @default.
• W1995853487 hasConcept C92316933 @default.
• W1995853487 hasConceptScore W1995853487C104317684 @default.
• W1995853487 hasConceptScore W1995853487C118303440 @default.
• W1995853487 hasConceptScore W1995853487C118892022 @default.
• W1995853487 hasConceptScore W1995853487C134018914 @default.
• W1995853487 hasConceptScore W1995853487C153911025 @default.
• W1995853487 hasConceptScore W1995853487C163170386 @default.
• W1995853487 hasConceptScore W1995853487C167625842 @default.
• W1995853487 hasConceptScore W1995853487C170493617 @default.
• W1995853487 hasConceptScore W1995853487C17971392 @default.
• W1995853487 hasConceptScore W1995853487C187882448 @default.
• W1995853487 hasConceptScore W1995853487C189482833 @default.
• W1995853487 hasConceptScore W1995853487C2779627488 @default.
• W1995853487 hasConceptScore W1995853487C36823959 @default.
• W1995853487 hasConceptScore W1995853487C53345823 @default.
• W1995853487 hasConceptScore W1995853487C54355233 @default.
• W1995853487 hasConceptScore W1995853487C86803240 @default.
• W1995853487 hasConceptScore W1995853487C92316933 @default.
• W1995853487 hasIssue "6" @default.
• W1995853487 hasLocation W19958534871 @default.
• W1995853487 hasLocation W19958534872 @default.
• W1995853487 hasOpenAccess W1995853487 @default.

• next