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• W1995855616 abstract "We investigate the effects on arterial PCO2 and on arterial-end tidal PCO2 difference of six different ventilation patterns of equal tidal volume, and also of various combinations of tidal volume and respiratory rate that maintain a constant alveolar ventilation. We use predictions from three different mathematical models. Models 1 (distributed) and 2 (compartmental) include combined convection and diffusion effects. Model 3 incorporates a single well-mixed alveolar compartment and an anatomical dead-space in which plug flow occurs. We found that: (i) breathing patterns with longer inspiratory times yield lower arterial PCO2; (ii) varying tidal volume and respiratory rate so that alveolar ventilation is kept constant may change both PaCO2 and the PaCO2–PetCO2 difference; (iii) the distributed model predicts higher end-tidal and arterial PCO2 than the compartmental models under similar conditions; and (iv) PCO2 capnograms predicted by the distributed model exhibit longer phase I and steeper phase II than other models." @default.
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• W1995855616 date "2002-08-01" @default.
• W1995855616 modified "2023-10-15" @default.
• W1995855616 title "The effects of ventilation pattern on carbon dioxide transfer in three computer models of the airways" @default.
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• W1995855616 doi "https://doi.org/10.1016/s1569-9048(02)00066-6" @default.
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