Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995863661> ?p ?o ?g. }
- W1995863661 endingPage "389" @default.
- W1995863661 startingPage "383" @default.
- W1995863661 abstract "Evidence suggests that lead and selected genes known to modify the toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and delta-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk. We report the relations among ALAD and VDR genotypes, three lead dose measures, and blood pressure and hypertension status in 798 Korean lead workers and 135 controls without occupational exposure to lead. Lead dose was assessed by blood lead, tibia lead measured by X-ray fluorescence, and dimercaptosuccinic acid (DMSA)-chelatable lead. Among lead workers, 9.9% (n = 79) were heterozygous for the ALAD(2) allele, and there were no ALAD(2) homozygotes; 11.2% (n = 89) had at least one copy of the VDR B allele, and 0.5% (n = 4) had the BB genotype. In linear regression models to control for covariates, VDR genotype (BB and Bb vs. bb), blood lead, tibia lead, and DMSA-chelatable lead were all positive predictors of systolic blood pressure. On average, lead workers with the VDR B allele, mainly heterozygotes, had systolic blood pressures that were 2.7-3.7 mm Hg higher than did workers with the bb genotype. VDR genotype was also associated with diastolic blood pressure; on average, lead workers with the VDR B allele had diastolic blood pressures that were 1.9-2.5 mm Hg higher than did lead workers with the VDR bb genotype (p = 0.04). VDR genotype modified the relation of age with systolic blood pressure; compared to lead workers with the VDR bb genotype, workers with the VDR B allele had larger elevations in blood pressure with increasing age. Lead workers with the VDR B allele also had a higher prevalence of hypertension compared to lead workers with the bb genotype [adjusted odds ratio (95% confidence interval) = 2.1 (1.0, 4.4), p = 0.05]. None of the lead biomarkers was associated with diastolic blood pressure, and tibia lead was the only lead dose measure that was a significant predictor of hypertension status. In contrast to VDR, ALAD genotype was not associated with the blood pressure measures and did not modify associations of the lead dose measures with any of the blood pressure measures. To our knowledge, these are the first data to suggest that the common genetic polymorphism in the VDR is associated with blood pressure and hypertension risk. We speculate that the BsmI polymorphism may be in linkage disequilibrium with another functional variant at the VDR locus or with a nearby gene." @default.
- W1995863661 created "2016-06-24" @default.
- W1995863661 creator A5009524646 @default.
- W1995863661 creator A5014395437 @default.
- W1995863661 creator A5040216288 @default.
- W1995863661 creator A5048979037 @default.
- W1995863661 creator A5049220752 @default.
- W1995863661 creator A5050569417 @default.
- W1995863661 creator A5082521828 @default.
- W1995863661 creator A5089443637 @default.
- W1995863661 date "2001-04-01" @default.
- W1995863661 modified "2023-10-03" @default.
- W1995863661 title "Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes." @default.
- W1995863661 cites W1582357630 @default.
- W1995863661 cites W1855515096 @default.
- W1995863661 cites W19081444 @default.
- W1995863661 cites W1966411863 @default.
- W1995863661 cites W1968527776 @default.
- W1995863661 cites W1971287276 @default.
- W1995863661 cites W1973813896 @default.
- W1995863661 cites W1975920835 @default.
- W1995863661 cites W1976979685 @default.
- W1995863661 cites W1980207364 @default.
- W1995863661 cites W1984193507 @default.
- W1995863661 cites W1987679215 @default.
- W1995863661 cites W1991951544 @default.
- W1995863661 cites W1992418427 @default.
- W1995863661 cites W1994203390 @default.
- W1995863661 cites W2007158870 @default.
- W1995863661 cites W2009124713 @default.
- W1995863661 cites W2009180025 @default.
- W1995863661 cites W2019117192 @default.
- W1995863661 cites W2020072854 @default.
- W1995863661 cites W2020682010 @default.
- W1995863661 cites W2025049088 @default.
- W1995863661 cites W2028356835 @default.
- W1995863661 cites W2028671018 @default.
- W1995863661 cites W2038202912 @default.
- W1995863661 cites W2040262552 @default.
- W1995863661 cites W2041709092 @default.
- W1995863661 cites W2043207235 @default.
- W1995863661 cites W2044305289 @default.
- W1995863661 cites W2056064631 @default.
- W1995863661 cites W2060054451 @default.
- W1995863661 cites W2062776508 @default.
- W1995863661 cites W2063378087 @default.
- W1995863661 cites W2065489166 @default.
- W1995863661 cites W2065620978 @default.
- W1995863661 cites W2067027353 @default.
- W1995863661 cites W2068224930 @default.
- W1995863661 cites W2069937931 @default.
- W1995863661 cites W2071258482 @default.
- W1995863661 cites W2079799322 @default.
- W1995863661 cites W2081692850 @default.
- W1995863661 cites W2082740217 @default.
- W1995863661 cites W2088837026 @default.
- W1995863661 cites W2089731460 @default.
- W1995863661 cites W2114086510 @default.
- W1995863661 cites W2115526102 @default.
- W1995863661 cites W2131565680 @default.
- W1995863661 cites W2150320532 @default.
- W1995863661 cites W2281708637 @default.
- W1995863661 cites W2313309609 @default.
- W1995863661 cites W2402240710 @default.
- W1995863661 cites W2411791710 @default.
- W1995863661 cites W4211039436 @default.
- W1995863661 cites W60012153 @default.
- W1995863661 doi "https://doi.org/10.1289/ehp.01109383" @default.
- W1995863661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1240279" @default.
- W1995863661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11335187" @default.
- W1995863661 hasPublicationYear "2001" @default.
- W1995863661 type Work @default.
- W1995863661 sameAs 1995863661 @default.
- W1995863661 citedByCount "42" @default.
- W1995863661 countsByYear W19958636612012 @default.
- W1995863661 countsByYear W19958636612013 @default.
- W1995863661 countsByYear W19958636612014 @default.
- W1995863661 countsByYear W19958636612015 @default.
- W1995863661 countsByYear W19958636612019 @default.
- W1995863661 countsByYear W19958636612020 @default.
- W1995863661 countsByYear W19958636612021 @default.
- W1995863661 countsByYear W19958636612022 @default.
- W1995863661 countsByYear W19958636612023 @default.
- W1995863661 crossrefType "journal-article" @default.
- W1995863661 hasAuthorship W1995863661A5009524646 @default.
- W1995863661 hasAuthorship W1995863661A5014395437 @default.
- W1995863661 hasAuthorship W1995863661A5040216288 @default.
- W1995863661 hasAuthorship W1995863661A5048979037 @default.
- W1995863661 hasAuthorship W1995863661A5049220752 @default.
- W1995863661 hasAuthorship W1995863661A5050569417 @default.
- W1995863661 hasAuthorship W1995863661A5082521828 @default.
- W1995863661 hasAuthorship W1995863661A5089443637 @default.
- W1995863661 hasBestOaLocation W19958636611 @default.
- W1995863661 hasConcept C104317684 @default.
- W1995863661 hasConcept C118552586 @default.
- W1995863661 hasConcept C124490489 @default.
- W1995863661 hasConcept C126322002 @default.
- W1995863661 hasConcept C134018914 @default.