FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995864057> ?p ?o ?g. }

• W1995864057 endingPage "S457" @default.
• W1995864057 startingPage "S457" @default.
• W1995864057 abstract "Recent studies have shown SBRT to be an effective treatment for selected patients with node-negative non–small cell lung cancer. Some data exist that suggest an increase in toxicity for central lesions, defined as those within 2 cm of the proximal tracheobronchial tree. We retrospectively evaluated patients treated with SBRT at our institution to determine whether central location of tumor predicted for inferior survival or increased toxicity. The records of the Indiana University Department of Radiation Oncology and Roudebush VAMC were screened for patients receiving SBRT for Stage I/II NSCLC. Patients were divided by central (n=31) or peripheral (n=249) lesion sites. Mann-Whitney rank-sum tests were performed comparing central and peripheral samples. chi-square tests were used to evaluate toxicity, local failure, and survival. Median follow-up was 15.3 months (range, 0.2–89.3 months) and was not different between groups. Between groups, there was no statistically significant difference in GTV or PTV size, dose per fraction, total dose, or number of beams used. Central lesions were treated with significantly more fractions (p = 0.03). There was no difference between central and peripheral cohorts in regard to local failure (chi-square p = 0.32) or overall survival (chi-square p = 0.69). There was also no difference in patients experiencing ≥ Grade 2 toxicity (chi-square p = 0.13); however, patients with central lesions had more ≥ Grade 3 toxicity (chi-square p = 0.017). In patients with central lesions, those treated with four or more fractions had fewer ≥ Grade 3 toxicities (1/13, 7.7%) than those treated with three fractions (5/19, 26.3%), but this difference did not reach statistical significance (chi-square p = 0.36). Local control and overall survival were similar in patients with central and peripheral lesions. Grade 3 and higher toxicities occurred more frequently in central tumors. Further exploration into the effect of increased fractionation on toxicity is warranted." @default.
• W1995864057 created "2016-06-24" @default.
• W1995864057 creator A5001697955 @default.
• W1995864057 creator A5002058845 @default.
• W1995864057 creator A5011539117 @default.
• W1995864057 creator A5019394129 @default.
• W1995864057 creator A5022485061 @default.
• W1995864057 creator A5043798566 @default.
• W1995864057 creator A5047546349 @default.
• W1995864057 creator A5075672758 @default.
• W1995864057 date "2009-11-01" @default.
• W1995864057 modified "2023-10-14" @default.
• W1995864057 title "Central Tumors in Node Negative Early-stage Non–small Cell Lung Cancer (NSCLC): Survival and Toxicity Outcomes following Stereotactic Body Radiation Therapy (SBRT)" @default.
• W1995864057 doi "https://doi.org/10.1016/j.ijrobp.2009.07.1045" @default.
• W1995864057 hasPublicationYear "2009" @default.
• W1995864057 type Work @default.
• W1995864057 sameAs 1995864057 @default.
• W1995864057 citedByCount "1" @default.
• W1995864057 countsByYear W19958640572015 @default.
• W1995864057 crossrefType "journal-article" @default.
• W1995864057 hasAuthorship W1995864057A5001697955 @default.
• W1995864057 hasAuthorship W1995864057A5002058845 @default.
• W1995864057 hasAuthorship W1995864057A5011539117 @default.
• W1995864057 hasAuthorship W1995864057A5019394129 @default.
• W1995864057 hasAuthorship W1995864057A5022485061 @default.
• W1995864057 hasAuthorship W1995864057A5043798566 @default.
• W1995864057 hasAuthorship W1995864057A5047546349 @default.
• W1995864057 hasAuthorship W1995864057A5075672758 @default.
• W1995864057 hasBestOaLocation W19958640571 @default.
• W1995864057 hasConcept C126322002 @default.
• W1995864057 hasConcept C143998085 @default.
• W1995864057 hasConcept C146357865 @default.
• W1995864057 hasConcept C151730666 @default.
• W1995864057 hasConcept C167135981 @default.
• W1995864057 hasConcept C2776256026 @default.
• W1995864057 hasConcept C2777714996 @default.
• W1995864057 hasConcept C2780387249 @default.
• W1995864057 hasConcept C29730261 @default.
• W1995864057 hasConcept C2989005 @default.
• W1995864057 hasConcept C509974204 @default.
• W1995864057 hasConcept C71924100 @default.
• W1995864057 hasConcept C86803240 @default.
• W1995864057 hasConceptScore W1995864057C126322002 @default.
• W1995864057 hasConceptScore W1995864057C143998085 @default.
• W1995864057 hasConceptScore W1995864057C146357865 @default.
• W1995864057 hasConceptScore W1995864057C151730666 @default.
• W1995864057 hasConceptScore W1995864057C167135981 @default.
• W1995864057 hasConceptScore W1995864057C2776256026 @default.
• W1995864057 hasConceptScore W1995864057C2777714996 @default.
• W1995864057 hasConceptScore W1995864057C2780387249 @default.
• W1995864057 hasConceptScore W1995864057C29730261 @default.
• W1995864057 hasConceptScore W1995864057C2989005 @default.
• W1995864057 hasConceptScore W1995864057C509974204 @default.
• W1995864057 hasConceptScore W1995864057C71924100 @default.
• W1995864057 hasConceptScore W1995864057C86803240 @default.
• W1995864057 hasIssue "3" @default.
• W1995864057 hasLocation W19958640571 @default.
• W1995864057 hasOpenAccess W1995864057 @default.
• W1995864057 hasPrimaryLocation W19958640571 @default.
• W1995864057 hasRelatedWork W2057693078 @default.
• W1995864057 hasRelatedWork W2095073570 @default.
• W1995864057 hasRelatedWork W2277416945 @default.
• W1995864057 hasRelatedWork W2366314651 @default.
• W1995864057 hasRelatedWork W2373558336 @default.
• W1995864057 hasRelatedWork W2395953112 @default.
• W1995864057 hasRelatedWork W2400217987 @default.
• W1995864057 hasRelatedWork W2407189953 @default.
• W1995864057 hasRelatedWork W2891061311 @default.
• W1995864057 hasRelatedWork W4291189777 @default.
• W1995864057 hasVolume "75" @default.
• W1995864057 isParatext "false" @default.
• W1995864057 isRetracted "false" @default.
• W1995864057 magId "1995864057" @default.
• W1995864057 workType "article" @default.