FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995864652> ?p ?o ?g. }

• W1995864652 endingPage "990" @default.
• W1995864652 startingPage "983" @default.
• W1995864652 abstract "<b>Background:</b> Transgenic deficiency in interferon γ (IFNγ) or IFNγ receptor makes resistant strains of mice bearing H-2^b or H-2^d susceptible to collagen induced arthritis (CIA). <b>Objective:</b> To determine whether the escape from regulation of disease susceptibility at the major histocompatibility complex level involves a new use of autoimmune T cells expressing T cell receptor (TCR) Vβ that vary from the cell populations previously identified within arthritic joints. <b>Methods:</b> Arthritis was induced by a standard protocol with type II bovine collagen (CII) in complete Freund’s adjuvant. Clinical features, histopathology, immunological responses, and TCR profile in arthritic joints in IFNγ knockout C57BL/6 (B6.IFNγ KO) mice (H-2^b) were compared directly with those in DBA/1 mice (H-2^q). <b>Results:</b> 60–80% of B6.IFNγ KO mice developed a progressive arthritis with a similar clinical course to classical CIA in DBA/1 mice. The affected joints in B6.IFNγ KO mice had an erosive form of arthritis with similar features to joint disease in DBA/1 mice. B6.IFNγ KO mice produced significantly higher levels of IgG2b and IgG1 autoantibodies to murine CII and showed increased proliferative response to CII compared with B6 mice. Comparable levels of interleukin 1β and tumour necrosis factor α expression were detected in arthritic joints from β6.IFNγ KO and DBA/1 mice. B6.IFNγKO mice used predominantly TCR Vβ6 and Vβ8 in arthritic joints. This TCR Vβ profile is similar to that found in DBA/1 mice with CIA. <b>Conclusions:</b> C57BL/6 mice deficient in IFNγ production can develop arthritis that resembles classical CIA. These data suggest that IFNγ is a key factor mediating susceptibility to CIA." @default.
• W1995864652 created "2016-06-24" @default.
• W1995864652 creator A5002255560 @default.
• W1995864652 creator A5014727739 @default.
• W1995864652 creator A5020170000 @default.
• W1995864652 creator A5027722199 @default.
• W1995864652 creator A5072766650 @default.
• W1995864652 date "2003-10-01" @default.
• W1995864652 modified "2023-09-24" @default.
• W1995864652 title "IFN deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor V 6 and V 8 in arthritic joints" @default.
• W1995864652 cites W118464054 @default.
• W1995864652 cites W1503666119 @default.
• W1995864652 cites W1539209639 @default.
• W1995864652 cites W1544658844 @default.
• W1995864652 cites W1559449746 @default.
• W1995864652 cites W1592311705 @default.
• W1995864652 cites W1917161620 @default.
• W1995864652 cites W1965003183 @default.
• W1995864652 cites W1986957921 @default.
• W1995864652 cites W1990645826 @default.
• W1995864652 cites W2008917915 @default.
• W1995864652 cites W2040232163 @default.
• W1995864652 cites W2040937120 @default.
• W1995864652 cites W2061776040 @default.
• W1995864652 cites W2083447506 @default.
• W1995864652 cites W2088616022 @default.
• W1995864652 cites W2088893866 @default.
• W1995864652 cites W2110361713 @default.
• W1995864652 cites W2111115841 @default.
• W1995864652 cites W2116594823 @default.
• W1995864652 cites W2130248979 @default.
• W1995864652 cites W2131112498 @default.
• W1995864652 cites W2131657975 @default.
• W1995864652 cites W2132932119 @default.
• W1995864652 cites W2134335195 @default.
• W1995864652 cites W2134768631 @default.
• W1995864652 cites W2144303909 @default.
• W1995864652 cites W2153463879 @default.
• W1995864652 cites W2154921493 @default.
• W1995864652 cites W2167379455 @default.
• W1995864652 cites W2327259952 @default.
• W1995864652 doi "https://doi.org/10.1136/ard.62.10.983" @default.
• W1995864652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1754310" @default.
• W1995864652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12972478" @default.
• W1995864652 hasPublicationYear "2003" @default.
• W1995864652 type Work @default.
• W1995864652 sameAs 1995864652 @default.
• W1995864652 citedByCount "71" @default.
• W1995864652 countsByYear W19958646522012 @default.
• W1995864652 countsByYear W19958646522013 @default.
• W1995864652 countsByYear W19958646522014 @default.
• W1995864652 countsByYear W19958646522015 @default.
• W1995864652 countsByYear W19958646522016 @default.
• W1995864652 countsByYear W19958646522017 @default.
• W1995864652 countsByYear W19958646522018 @default.
• W1995864652 countsByYear W19958646522020 @default.
• W1995864652 countsByYear W19958646522021 @default.
• W1995864652 countsByYear W19958646522022 @default.
• W1995864652 countsByYear W19958646522023 @default.
• W1995864652 crossrefType "journal-article" @default.
• W1995864652 hasAuthorship W1995864652A5002255560 @default.
• W1995864652 hasAuthorship W1995864652A5014727739 @default.
• W1995864652 hasAuthorship W1995864652A5020170000 @default.
• W1995864652 hasAuthorship W1995864652A5027722199 @default.
• W1995864652 hasAuthorship W1995864652A5072766650 @default.
• W1995864652 hasBestOaLocation W19958646521 @default.
• W1995864652 hasConcept C153911025 @default.
• W1995864652 hasConcept C159654299 @default.
• W1995864652 hasConcept C163764329 @default.
• W1995864652 hasConcept C19317047 @default.
• W1995864652 hasConcept C203014093 @default.
• W1995864652 hasConcept C2776090121 @default.
• W1995864652 hasConcept C2777077863 @default.
• W1995864652 hasConcept C2777575956 @default.
• W1995864652 hasConcept C2779075594 @default.
• W1995864652 hasConcept C2780130043 @default.
• W1995864652 hasConcept C2781013607 @default.
• W1995864652 hasConcept C71924100 @default.
• W1995864652 hasConcept C86803240 @default.
• W1995864652 hasConcept C8891405 @default.
• W1995864652 hasConceptScore W1995864652C153911025 @default.
• W1995864652 hasConceptScore W1995864652C159654299 @default.
• W1995864652 hasConceptScore W1995864652C163764329 @default.
• W1995864652 hasConceptScore W1995864652C19317047 @default.
• W1995864652 hasConceptScore W1995864652C203014093 @default.
• W1995864652 hasConceptScore W1995864652C2776090121 @default.
• W1995864652 hasConceptScore W1995864652C2777077863 @default.
• W1995864652 hasConceptScore W1995864652C2777575956 @default.
• W1995864652 hasConceptScore W1995864652C2779075594 @default.
• W1995864652 hasConceptScore W1995864652C2780130043 @default.
• W1995864652 hasConceptScore W1995864652C2781013607 @default.
• W1995864652 hasConceptScore W1995864652C71924100 @default.
• W1995864652 hasConceptScore W1995864652C86803240 @default.
• W1995864652 hasConceptScore W1995864652C8891405 @default.
• W1995864652 hasIssue "10" @default.
• W1995864652 hasLocation W19958646521 @default.
• W1995864652 hasLocation W19958646522 @default.
• W1995864652 hasLocation W19958646523 @default.

• next