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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995869884> ?p ?o ?g. }

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• W1995869884 abstract "We examined the transport capacity in Xenopus laevis oocytes of human EST KIAA0822/ABCA8, a member of the ABC superfamily. Substrates of ABCC2/MRP-2 such as [14C]estradiol-beta-glucuronide, taurocholate, and LTC4, and of organic anion transporter (OAT), such as para-aminohippuric acid, ochratoxin-A, were significantly accumulated while tetraethylammonium and doxorubicin were not. The transport of [14C]estradiol-beta-glucuronide was ATP-dependent and K(m) and V(max) values of 30.4microM and 66.9pmol/h/egg, respectively, were estimated. The transport of [14C]estradiol-beta-glucuronide was inhibited by substrates/inhibitors of ABCC2/MRP-2, but not by those of the organic cation transporter and multidrug resistance protein (MDR)-1. KIAA0822/ABCA8 possesses two ATP-binding sites and fourteen transmembrane domains. Northern blot analysis revealed expression in most organs, especially in heart, skeletal muscle, and liver. Thus, ABCA8 is a new member of the xenobiotic transporter ABC-subfamily." @default.
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• W1995869884 date "2002-10-01" @default.
• W1995869884 modified "2023-10-02" @default.
• W1995869884 title "Functional analysis of ABCA8, a new drug transporter" @default.
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• W1995869884 doi "https://doi.org/10.1016/s0006-291x(02)02389-6" @default.
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