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• W1995874433 abstract "Monocyte-derived macrophages (MDM) infected in vitro with a macrophage-tropic strain of human immunodeficiency virus (HIV) fused with uninfected, CD4-expressing T lymphoblastoid cells, but not with a subclone of these cells lacking surface CD4. Infected MDM also fused with uninfected autologous and heterologous MDM. Recombinant soluble CD4 protein (rsCD4) (10 μg/ml) and full-length recombinant glycosylated gp120 (20 μg/ml) each inhibited fusion by 94–99%; the inhibition was dose-dependent. The N-terminal portion of gp120 did not inhibit syncytium formation. Fusion was also inhibited by a monoclonal antibody to an epitope which binds gp120 (S3.5), but not by antibody to an epitope not involved in gp120 binding (OKT4). HIV-infected MDM specifically bound fluorescein-conjugated rsCD4, and virus could be visualized budding from the surface of these cells. HIV-infected MDM express viral gp120 on their surface and fuse with CD4-bearing cells in a fashion similar to lymphoid cells. Macrophages may contribute to CD4 lymphocyte depletion in vivo by this fusion mechanism." @default.
• W1995874433 created "2016-06-24" @default.
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• W1995874433 date "1992-11-01" @default.
• W1995874433 modified "2023-09-27" @default.
• W1995874433 title "Human immunodeficiency virus-infected monocyte-derived macrophages express surface GP120 and fuse with CD4 lymphoid cells in vitro: A possible mechanism of T lymphocyte depletion in vivo" @default.
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• W1995874433 doi "https://doi.org/10.1016/0090-1229(92)90217-c" @default.
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