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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995874501> ?p ?o ?g. }

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• W1995874501 abstract "Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure–activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R4 and R5 positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI = 26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation." @default.
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• W1995874501 date "2011-10-01" @default.
• W1995874501 modified "2023-10-18" @default.
• W1995874501 title "Synthesis, structure–activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors" @default.
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• W1995874501 doi "https://doi.org/10.1016/j.bmcl.2011.08.002" @default.
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