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• W1995901717 abstract "Abstract Natural products and their derivatives have been an invaluable source of drug leads for the pharmaceutical industry over the past decades, especially for antibacterial and anticancer purposes. Nature products, with their chemical diversity and biochemical specificity, are ideal starting points of drug development. Rational drug design based on natural product scaffolds, however, was hindered by a lack of knowledge regarding their mechanisms of action. Advances in proteomic technologies hold the key to revolutionize the target identification of natural products. In this regard, chemical proteomics have demonstrated the capabilities to identify specific targets by screening against the proteome. On the other hand, high‐throughput proteome analysis reveals the multiple impacts of drug‐target interaction in a global context, providing insights for elucidation of signaling pathways involved in the drug response, and uncovering predictive markers of drug efficacy and toxicity. Increasingly, studies have exploited integration of transcriptome and proteome datasets, which offers additional information on regulation of molecular network at transcriptional and post‐translational levels. In this review, we discuss major proteomic approaches applied to studying the mechanism of action of natural products and merits of combining datasets from proteomics and transcriptomics analysis." @default.
• W1995901717 created "2016-06-24" @default.
• W1995901717 creator A5012921461 @default.
• W1995901717 creator A5020167546 @default.
• W1995901717 creator A5053483245 @default.
• W1995901717 creator A5069893086 @default.
• W1995901717 date "2008-03-01" @default.
• W1995901717 modified "2023-09-30" @default.
• W1995901717 title "Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses" @default.
• W1995901717 cites W1486948598 @default.
• W1995901717 cites W1495610572 @default.
• W1995901717 cites W1597678601 @default.
• W1995901717 cites W1639582946 @default.
• W1995901717 cites W1647597862 @default.
• W1995901717 cites W1669562987 @default.
• W1995901717 cites W1941117044 @default.
• W1995901717 cites W1964378600 @default.
• W1995901717 cites W1964778251 @default.
• W1995901717 cites W1967567333 @default.
• W1995901717 cites W1973152657 @default.
• W1995901717 cites W1978052114 @default.
• W1995901717 cites W1978443443 @default.
• W1995901717 cites W1978964523 @default.
• W1995901717 cites W1979542564 @default.
• W1995901717 cites W1980145652 @default.
• W1995901717 cites W1983937766 @default.
• W1995901717 cites W1985173354 @default.
• W1995901717 cites W1985692894 @default.
• W1995901717 cites W1987242103 @default.
• W1995901717 cites W1994193027 @default.
• W1995901717 cites W1998913896 @default.
• W1995901717 cites W2000109838 @default.
• W1995901717 cites W2000430156 @default.
• W1995901717 cites W2003407908 @default.
• W1995901717 cites W2004799012 @default.
• W1995901717 cites W2007515181 @default.
• W1995901717 cites W2007783249 @default.
• W1995901717 cites W2008883486 @default.
• W1995901717 cites W2015358023 @default.
• W1995901717 cites W2016086822 @default.
• W1995901717 cites W2016153572 @default.
• W1995901717 cites W2022019019 @default.
• W1995901717 cites W2022864303 @default.
• W1995901717 cites W2028735872 @default.
• W1995901717 cites W2031066980 @default.
• W1995901717 cites W2031343644 @default.
• W1995901717 cites W2032210210 @default.
• W1995901717 cites W2032299467 @default.
• W1995901717 cites W2036976244 @default.
• W1995901717 cites W2048652222 @default.
• W1995901717 cites W2049048127 @default.
• W1995901717 cites W2051966153 @default.
• W1995901717 cites W2052150348 @default.
• W1995901717 cites W2054198239 @default.
• W1995901717 cites W2054307806 @default.
• W1995901717 cites W2056688696 @default.
• W1995901717 cites W2057084845 @default.
• W1995901717 cites W2062937323 @default.
• W1995901717 cites W2067110167 @default.
• W1995901717 cites W2068635825 @default.
• W1995901717 cites W2073206600 @default.
• W1995901717 cites W2073938056 @default.
• W1995901717 cites W2077124171 @default.
• W1995901717 cites W2077152516 @default.
• W1995901717 cites W2077994180 @default.
• W1995901717 cites W2078732389 @default.
• W1995901717 cites W2080328450 @default.
• W1995901717 cites W2084702659 @default.
• W1995901717 cites W2087614968 @default.
• W1995901717 cites W2088807388 @default.
• W1995901717 cites W2089786416 @default.
• W1995901717 cites W2091246008 @default.
• W1995901717 cites W2092555898 @default.
• W1995901717 cites W2093543062 @default.
• W1995901717 cites W2095186218 @default.
• W1995901717 cites W2095863326 @default.
• W1995901717 cites W2099928393 @default.
• W1995901717 cites W2102149615 @default.
• W1995901717 cites W2103782786 @default.
• W1995901717 cites W2104382960 @default.
• W1995901717 cites W2107257265 @default.
• W1995901717 cites W2108196738 @default.
• W1995901717 cites W2110484017 @default.
• W1995901717 cites W2114756704 @default.
• W1995901717 cites W2115346062 @default.
• W1995901717 cites W2118577784 @default.
• W1995901717 cites W2128898348 @default.
• W1995901717 cites W2132208874 @default.
• W1995901717 cites W2132647801 @default.
• W1995901717 cites W2138019658 @default.
• W1995901717 cites W2139985446 @default.
• W1995901717 cites W2141380742 @default.
• W1995901717 cites W2141474275 @default.
• W1995901717 cites W2143364665 @default.
• W1995901717 cites W2145842062 @default.
• W1995901717 cites W2146280432 @default.
• W1995901717 cites W2147012175 @default.
• W1995901717 cites W2148986879 @default.

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