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• W1995916680 abstract "<i>Background:</i> The safety and efficacy of cefpirome (CPM), a fourth-generation cephalosporin, has not yet been studied in an Asian population. <i>Methods:</i> Sixty-nine adult Chinese patients with sepsis due to bacterial infections were enrolled in the study and randomly assigned to receive CPM (2 g i.v. every 12 h) or ceftazidime (2 g i.v. every 8 h). <i>Results:</i> Both groups were comparable in terms of demographic, clinical and microbiological features. The causative pathogen was <i>Escherichia coli</i> or <i>Klebsiella pneumoniae</i> in the majority of microbiologically documented cases. The rates of clinical response (94 vs. 94%) and bacteriological response (65 vs. 68%) were similar in both groups. Similar adverse events, including rashes, gastrointestinal upset and asymptomatic elevation of hepatic enzymes, occurred in a minority of patients in both groups. All events were self-limited after discontinuation of the drugs. <i>Conclusion:</i> CPM is as safe and effective as ceftazidime in the treatment of sepsis due to bacterial infections in Chinese patients." @default.
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• W1995916680 date "2000-01-01" @default.
• W1995916680 modified "2023-10-18" @default.
• W1995916680 title "Safety and Efficacy of Cefpirome in Comparison with Ceftazidime in Chinese Patients with Sepsis due to Bacterial Infections" @default.
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• W1995916680 doi "https://doi.org/10.1159/000007311" @default.
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