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- W1995920325 abstract "In order to explore the protective function of human glutathione S-transferase π(GST-π) in vitro and in vivo, transfected NIH 3T3 clones were examined in cytotoxicity assays using the carcinogen ( ± )anti-benzo(a)pyrene 7,8-diol-9,10-epoxide (BPDE) or inoculated into nude mice and treated with the carcinogen benzo(a)pyrene (BP) to induce tumor formation. The human GST-π cDNA under the control of the murine α2-collagen promoter was transfected into NIH 3T3 cells and G418 resistant clones were analyzed by Southern, Northern, Western, and two-dimensional analysis. Clone A2 stably expressed human GST-π and has 2.5-fold greater activity toward the substrate 1-chloro-2,4-dinitrobenzene and a 1.7-fold increase in LD50 for BPDE in vitro when compared to control-transfected clone G3. This increase in protection, however, did not prevent the formation of BP-induced tumors in vivo." @default.
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- W1995920325 date "1995-01-01" @default.
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- W1995920325 title "Overexpression of Human Glutathione S-Transf erase π Protects NIH 3T3 Cells against ( ± )Anti BPDE Cytotoxicity but Not Tumor Formation" @default.
- W1995920325 doi "https://doi.org/10.1159/000163952" @default.
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