FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995926520> ?p ?o ?g. }

• W1995926520 endingPage "2153" @default.
• W1995926520 startingPage "2147" @default.
• W1995926520 abstract "We investigated the safety and pharmacodynamics of escalating doses of recombinant nematode anticoagulant protein c2 (rNAPc2) in patients undergoing elective coronary angioplasty.Recombinant NAPc2 is a potent inhibitor of the tissue factor/factor VIIa complex, which has the potential to reduce the risk of thrombotic complications in coronary artery disease.In a randomized, double-blinded, dose-escalation, multicenter trial, 154 patients received placebo or rNAPc2 at doses of 3.5, 5.0, 7.5, and 10.0 microg/kg body weight as a single subcutaneous administration 2 to 6 h before angioplasty. All patients received aspirin, unfractionated heparin during angioplasty, and clopidogrel in case of stent implantation.Minor bleeding rates for the doses 3.5 to 7.5 microg/kg were comparable to that with placebo (6.7%), whereas an incidence of 26.9% was observed at the 10.0 microg/kg dose level (p < 0.01). Major bleedings occurred in the 5.0 microg/kg (n = 3) and 7.5 microg/kg (n = 1) dose groups. The three patients in the 5.0 microg/kg dose group also received a glycoprotein IIb/IIIa receptor inhibitor at the moment of major bleeding. Systemic thrombin generation, as measured by prothrombin fragment 1+2 (F(1+2)), was suppressed in all rNAPc2 dose groups to levels below pretreatment values for at least 36 h. In the placebo group, a distinct increase of F(1+2) levels was observed following cessation of heparin.Inhibition of the tissue factor/factor VIIa complex with rNAPc2, at doses up to 7.5 microg/kg, in combination with aspirin, clopidogrel, and unfractionated heparin appears to be a safe and effective strategy to prevent thrombin generation during coronary angioplasty." @default.
• W1995926520 created "2016-06-24" @default.
• W1995926520 creator A5006701743 @default.
• W1995926520 creator A5014046875 @default.
• W1995926520 creator A5014653223 @default.
• W1995926520 creator A5026028911 @default.
• W1995926520 creator A5039204383 @default.
• W1995926520 creator A5042290277 @default.
• W1995926520 creator A5047779930 @default.
• W1995926520 creator A5053389599 @default.
• W1995926520 date "2003-06-01" @default.
• W1995926520 modified "2023-10-16" @default.
• W1995926520 title "Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplastyAppendix" @default.
• W1995926520 cites W114021389 @default.
• W1995926520 cites W1593759404 @default.
• W1995926520 cites W1971585818 @default.
• W1995926520 cites W1990882948 @default.
• W1995926520 cites W1997795038 @default.
• W1995926520 cites W1998166048 @default.
• W1995926520 cites W2062893657 @default.
• W1995926520 cites W2066001927 @default.
• W1995926520 cites W2073866408 @default.
• W1995926520 cites W2078415463 @default.
• W1995926520 cites W2083679231 @default.
• W1995926520 cites W2103971185 @default.
• W1995926520 cites W2107151252 @default.
• W1995926520 cites W2142308531 @default.
• W1995926520 cites W2152307503 @default.
• W1995926520 cites W2159822842 @default.
• W1995926520 cites W2163426803 @default.
• W1995926520 cites W2167402278 @default.
• W1995926520 cites W2313726388 @default.
• W1995926520 cites W4254730674 @default.
• W1995926520 doi "https://doi.org/10.1016/s0735-1097(03)00478-9" @default.
• W1995926520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12821239" @default.
• W1995926520 hasPublicationYear "2003" @default.
• W1995926520 type Work @default.
• W1995926520 sameAs 1995926520 @default.
• W1995926520 citedByCount "101" @default.
• W1995926520 countsByYear W19959265202012 @default.
• W1995926520 countsByYear W19959265202013 @default.
• W1995926520 countsByYear W19959265202014 @default.
• W1995926520 countsByYear W19959265202015 @default.
• W1995926520 countsByYear W19959265202016 @default.
• W1995926520 countsByYear W19959265202017 @default.
• W1995926520 countsByYear W19959265202018 @default.
• W1995926520 countsByYear W19959265202019 @default.
• W1995926520 countsByYear W19959265202020 @default.
• W1995926520 countsByYear W19959265202022 @default.
• W1995926520 countsByYear W19959265202023 @default.
• W1995926520 crossrefType "journal-article" @default.
• W1995926520 hasAuthorship W1995926520A5006701743 @default.
• W1995926520 hasAuthorship W1995926520A5014046875 @default.
• W1995926520 hasAuthorship W1995926520A5014653223 @default.
• W1995926520 hasAuthorship W1995926520A5026028911 @default.
• W1995926520 hasAuthorship W1995926520A5039204383 @default.
• W1995926520 hasAuthorship W1995926520A5042290277 @default.
• W1995926520 hasAuthorship W1995926520A5047779930 @default.
• W1995926520 hasAuthorship W1995926520A5053389599 @default.
• W1995926520 hasConcept C111113717 @default.
• W1995926520 hasConcept C112705442 @default.
• W1995926520 hasConcept C126322002 @default.
• W1995926520 hasConcept C141071460 @default.
• W1995926520 hasConcept C142724271 @default.
• W1995926520 hasConcept C186738567 @default.
• W1995926520 hasConcept C204787440 @default.
• W1995926520 hasConcept C27081682 @default.
• W1995926520 hasConcept C2777151630 @default.
• W1995926520 hasConcept C2777557582 @default.
• W1995926520 hasConcept C2777628954 @default.
• W1995926520 hasConcept C2777849778 @default.
• W1995926520 hasConcept C2778205648 @default.
• W1995926520 hasConcept C2778382381 @default.
• W1995926520 hasConcept C2778961111 @default.
• W1995926520 hasConcept C2780326628 @default.
• W1995926520 hasConcept C2780930249 @default.
• W1995926520 hasConcept C42219234 @default.
• W1995926520 hasConcept C71924100 @default.
• W1995926520 hasConcept C90924648 @default.
• W1995926520 hasConcept C98274493 @default.
• W1995926520 hasConceptScore W1995926520C111113717 @default.
• W1995926520 hasConceptScore W1995926520C112705442 @default.
• W1995926520 hasConceptScore W1995926520C126322002 @default.
• W1995926520 hasConceptScore W1995926520C141071460 @default.
• W1995926520 hasConceptScore W1995926520C142724271 @default.
• W1995926520 hasConceptScore W1995926520C186738567 @default.
• W1995926520 hasConceptScore W1995926520C204787440 @default.
• W1995926520 hasConceptScore W1995926520C27081682 @default.
• W1995926520 hasConceptScore W1995926520C2777151630 @default.
• W1995926520 hasConceptScore W1995926520C2777557582 @default.
• W1995926520 hasConceptScore W1995926520C2777628954 @default.
• W1995926520 hasConceptScore W1995926520C2777849778 @default.
• W1995926520 hasConceptScore W1995926520C2778205648 @default.
• W1995926520 hasConceptScore W1995926520C2778382381 @default.
• W1995926520 hasConceptScore W1995926520C2778961111 @default.
• W1995926520 hasConceptScore W1995926520C2780326628 @default.
• W1995926520 hasConceptScore W1995926520C2780930249 @default.
• W1995926520 hasConceptScore W1995926520C42219234 @default.

• next