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• W1995929497 abstract "Different Hypericum species such as Hypericum perforatum (HP) L. and Hypericum triquetrifolium Turra are well known and widely used traditional medicine in Turkey.We investigated the effect of standardized HP extract on endothelium and vascular function.After suspending the aortas with endothelium in organ baths containing Krebs solution, contractile and relaxant responses were assessed in the absence and presence of HP (0.05 mg/ml).Although there were significant reductions in the contractile responses to phenylephrine (1113.73 ± 164.11; 477.40 ± 39.94; p < 0.05) and potassium chloride (745.58 ± 66.73; 112.58 ± 26.58; p < 0.05), no differences in the relaxant responses to acetylcholine (94.61 ± 2.65; 87.79 ± 9.40) and sodium nitroprusside (108.82 ± 5.06; 106.43 ± 7.45) were observed.These data suggest that even the high dose of HP intervention does not bring any harmful effect on endothelium and smooth muscle function; meanwhile it might be beneficial on some of diseases accompanied with increased vascular contraction." @default.
• W1995929497 created "2016-06-24" @default.
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• W1995929497 date "2011-05-18" @default.
• W1995929497 modified "2023-10-15" @default.
• W1995929497 title "The effect ofHypericum perforatumon isolated rat aorta" @default.
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• W1995929497 doi "https://doi.org/10.3109/13880209.2010.551779" @default.
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