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• W1995933145 startingPage "97" @default.
• W1995933145 abstract "Glucocorticoid hormones exert crucial effects on the brain in relation to physiology, endocrine regulation, mood and cognition. Their two receptor types, glucocorticoid and mineralocorticoid receptors (GR and MR), are members of the nuclear receptor superfamily and act in large measure as transcription factors. The outcome of MR/GR action on the genome depends on interaction with members from different protein families, which are of crucial importance for cross-talk with other neuronal and hormonal signals that impinge on the glucocorticoid sensitive circuitry. Relevant interacting proteins include other transcription factors that may either tether the receptor to the DNA, or that bind in the vicinity of GR and MR to tune the transcriptional response. In addition, transcriptional coregulator proteins constitute the actual signal transduction pathway to the transcription machinery. We review the current evidence for involvement of individual coregulators in GR-dependent effects on stress responses, and learning and memory. We discuss the use of in vitro and in silico tools to predict those coregulators that are of importance for particular brain processes. Finally, we discuss the potential of selective receptor modulators that may only allow a subset of all interactions, thus allowing more selective targeting of glucocorticoid-dependent processes in the brain." @default.
• W1995933145 created "2016-06-24" @default.
• W1995933145 creator A5039593796 @default.
• W1995933145 creator A5045828654 @default.
• W1995933145 creator A5068994703 @default.
• W1995933145 date "2013-07-01" @default.
• W1995933145 modified "2023-10-16" @default.
• W1995933145 title "Understanding stress-effects in the brain via transcriptional signal transduction pathways" @default.
• W1995933145 cites W117282844 @default.
• W1995933145 cites W1570880313 @default.
• W1995933145 cites W1646199134 @default.
• W1995933145 cites W1798968129 @default.
• W1995933145 cites W1893871726 @default.
• W1995933145 cites W1900657670 @default.
• W1995933145 cites W1963551704 @default.
• W1995933145 cites W1963740481 @default.
• W1995933145 cites W1968932167 @default.
• W1995933145 cites W1974032891 @default.
• W1995933145 cites W1975890998 @default.
• W1995933145 cites W1979178661 @default.
• W1995933145 cites W1982519328 @default.
• W1995933145 cites W1986252957 @default.
• W1995933145 cites W1988134422 @default.
• W1995933145 cites W1989673575 @default.
• W1995933145 cites W1995820701 @default.
• W1995933145 cites W1995910160 @default.
• W1995933145 cites W1997510672 @default.
• W1995933145 cites W1998486709 @default.
• W1995933145 cites W1998769481 @default.
• W1995933145 cites W1998952587 @default.
• W1995933145 cites W1999267945 @default.
• W1995933145 cites W1999319214 @default.
• W1995933145 cites W2000627237 @default.
• W1995933145 cites W2002295425 @default.
• W1995933145 cites W2002433012 @default.
• W1995933145 cites W2007535557 @default.
• W1995933145 cites W2007715300 @default.
• W1995933145 cites W2010339265 @default.
• W1995933145 cites W2010345670 @default.
• W1995933145 cites W2012155675 @default.
• W1995933145 cites W2014042333 @default.
• W1995933145 cites W2015040514 @default.
• W1995933145 cites W2015816977 @default.
• W1995933145 cites W2018057094 @default.
• W1995933145 cites W2018328431 @default.
• W1995933145 cites W2019010829 @default.
• W1995933145 cites W2020709072 @default.
• W1995933145 cites W2020896282 @default.
• W1995933145 cites W2021067562 @default.
• W1995933145 cites W2023701514 @default.
• W1995933145 cites W2026236554 @default.
• W1995933145 cites W2031215168 @default.
• W1995933145 cites W2031431435 @default.
• W1995933145 cites W2032146477 @default.
• W1995933145 cites W2032340987 @default.
• W1995933145 cites W2032945989 @default.
• W1995933145 cites W2035162632 @default.
• W1995933145 cites W2037276920 @default.
• W1995933145 cites W2037412924 @default.
• W1995933145 cites W2039999877 @default.
• W1995933145 cites W2040310712 @default.
• W1995933145 cites W2044045263 @default.
• W1995933145 cites W2047788639 @default.
• W1995933145 cites W2051859809 @default.
• W1995933145 cites W2052347419 @default.
• W1995933145 cites W2052500168 @default.
• W1995933145 cites W2053125671 @default.
• W1995933145 cites W2053492909 @default.
• W1995933145 cites W2058081875 @default.
• W1995933145 cites W2058105213 @default.
• W1995933145 cites W2064874105 @default.
• W1995933145 cites W2065432433 @default.
• W1995933145 cites W2066323798 @default.
• W1995933145 cites W2068113812 @default.
• W1995933145 cites W2068927082 @default.
• W1995933145 cites W2068987819 @default.
• W1995933145 cites W2069353840 @default.
• W1995933145 cites W2071489529 @default.
• W1995933145 cites W2074424302 @default.
• W1995933145 cites W2076515074 @default.
• W1995933145 cites W2078132872 @default.
• W1995933145 cites W2080292781 @default.
• W1995933145 cites W2081825803 @default.
• W1995933145 cites W2082938876 @default.
• W1995933145 cites W2084533978 @default.
• W1995933145 cites W2087133844 @default.
• W1995933145 cites W2088817213 @default.
• W1995933145 cites W2094638661 @default.
• W1995933145 cites W2095060581 @default.
• W1995933145 cites W2096081114 @default.
• W1995933145 cites W2098808351 @default.
• W1995933145 cites W2099441867 @default.
• W1995933145 cites W2099710186 @default.
• W1995933145 cites W2103567375 @default.
• W1995933145 cites W2105117184 @default.
• W1995933145 cites W2107307200 @default.
• W1995933145 cites W2111878770 @default.
• W1995933145 cites W2113505474 @default.

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