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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995950360> ?p ?o ?g. }

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• W1995950360 abstract "Tissue-engineering is considered a promising avenue for developing human articular cartilage implants that can be employed for resurfacing damaged cartilage in the early stages of osteoarthritis. In the present study, human cartilage-constructs were produced from human osteoarthritic chondrocytes maintained on a scaffold of HYAFF®-11 in perfusion mini-bioreactors or after implantation and recovery from nude or SCID mice after 3 weeks. The human cartilage-construct extracellular matrix reacted positively with anti-Type II collagen monoclonal antibody, but not with anti-Type I or anti-Type X collagen monoclonal antibodies. A significant portion of the cartilage-construct extracellular matrix stained metachromatic with Toluidine blue-O indicative of sulfated-proteoglycan deposition. Cyclic hydrostatic pressure applied for 4 hrs at 5 MPa using a 1 Hertz sinusoidal frequency significantly increased (p < 0.02) the proportion of apoptotic cells in the cartilage-constructs (41% ± 4.2%; mean ± SD) compared to control cartilage-constructs (28.5 ± 8.4%)." @default.
• W1995950360 created "2016-06-24" @default.
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• W1995950360 date "2006-01-01" @default.
• W1995950360 modified "2023-10-14" @default.
• W1995950360 title "Hydrostatic Pressure Increases Apoptosis in Cartilage-Constructs Produced From Human Osteoarthritic Chondrocytes" @default.
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• W1995950360 doi "https://doi.org/10.2741/1914" @default.
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