Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995952010> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1995952010 endingPage "297" @default.
- W1995952010 startingPage "288" @default.
- W1995952010 abstract "Heparin, currently used in extracorporeal blood circulation procedures, may lead to hemorrhagic complications. Protamine, used for reversal of heparin-induced anticoagulation at the end of such procedures, can cause adverse hemodynamic responses. To prevent both types of complications, we have developed a reactor device containing immobilized protamine (i.e., a protamine bio-reactor) that can be placed at the distal end of the circuit, thus providing simultaneous extracorporeal heparin removal and protamine treatment. In preliminary in vivo studies involving dogs at a blood flow of 100 ml/min, the bio-reactor removed about 50% of the administered dose of heparin (i.e., 100 units/kg) in 10 min. While rapid injection of protamine in dogs anticoagulated with heparin produced a transient and significant (P less than 0.005) decreases in systemic arterial blood pressure (-39.5 +/- 9.2 mmHg), cardiac output (-1.59 +/- 0.23 L/min), and mixed venous oxygen saturation (-7.5 +/- 1.3%) and increases in pulmonary artery systolic (+12.7 +/- 4.4 mmHg) and diastolic pressures (+10.0 +/- 3.6 mmHg), the use of the protamine bio-reactor did not elicit any statistically significant change in any of the variables measured. Hemolysis was not significant, as reflected by a statistically insignificant change of the animals' red blood cell counts, hematocrits, and total hemoglobin values. In addition, hemolytic complement was found to be reduced only by 10% in animals with the protamine bio-reactor, whereas it was reduced rapidly by 20% in animals receiving intravenous protamine administration and progressively by 20% in control animals with a sham reactor that contained no protamine. Furthermore, the use of the protamine bio-reactor also significantly reduced the protamine-induced transient thrombocytopenic and granulocytopenic responses. The white blood cell counts and platelet counts decreased to 87.7 +/- 7.5 and 83.3 +/- 5.0% of baseline, respectively, in dogs with the protamine bio-reactor compared to 35.5 +/- 14.3 and 32.1 +/- 8.1% of baseline in dogs receiving intravenous protamine. The protamine bio-reactor may provide a unique means to simultaneously control both heparin- and protamine-induced complications." @default.
- W1995952010 created "2016-06-24" @default.
- W1995952010 creator A5011645831 @default.
- W1995952010 creator A5030829829 @default.
- W1995952010 creator A5035826601 @default.
- W1995952010 creator A5051865218 @default.
- W1995952010 creator A5075997575 @default.
- W1995952010 creator A5084369211 @default.
- W1995952010 date "1991-08-01" @default.
- W1995952010 modified "2023-10-15" @default.
- W1995952010 title "The Use of Immobilized Protamine in Removing Heparin and Preventing Protamine-induced Complications during Extracorporeal Blood Circulation" @default.
- W1995952010 doi "https://doi.org/10.1097/00000542-199108000-00017" @default.
- W1995952010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1859016" @default.
- W1995952010 hasPublicationYear "1991" @default.
- W1995952010 type Work @default.
- W1995952010 sameAs 1995952010 @default.
- W1995952010 citedByCount "26" @default.
- W1995952010 countsByYear W19959520102013 @default.
- W1995952010 countsByYear W19959520102014 @default.
- W1995952010 countsByYear W19959520102022 @default.
- W1995952010 crossrefType "journal-article" @default.
- W1995952010 hasAuthorship W1995952010A5011645831 @default.
- W1995952010 hasAuthorship W1995952010A5030829829 @default.
- W1995952010 hasAuthorship W1995952010A5035826601 @default.
- W1995952010 hasAuthorship W1995952010A5051865218 @default.
- W1995952010 hasAuthorship W1995952010A5075997575 @default.
- W1995952010 hasAuthorship W1995952010A5084369211 @default.
- W1995952010 hasBestOaLocation W19959520101 @default.
- W1995952010 hasConcept C126322002 @default.
- W1995952010 hasConcept C164705383 @default.
- W1995952010 hasConcept C178853913 @default.
- W1995952010 hasConcept C2777557582 @default.
- W1995952010 hasConcept C2779354726 @default.
- W1995952010 hasConcept C2779902561 @default.
- W1995952010 hasConcept C2779915274 @default.
- W1995952010 hasConcept C2780835560 @default.
- W1995952010 hasConcept C2994232697 @default.
- W1995952010 hasConcept C42219234 @default.
- W1995952010 hasConcept C71924100 @default.
- W1995952010 hasConcept C98274493 @default.
- W1995952010 hasConceptScore W1995952010C126322002 @default.
- W1995952010 hasConceptScore W1995952010C164705383 @default.
- W1995952010 hasConceptScore W1995952010C178853913 @default.
- W1995952010 hasConceptScore W1995952010C2777557582 @default.
- W1995952010 hasConceptScore W1995952010C2779354726 @default.
- W1995952010 hasConceptScore W1995952010C2779902561 @default.
- W1995952010 hasConceptScore W1995952010C2779915274 @default.
- W1995952010 hasConceptScore W1995952010C2780835560 @default.
- W1995952010 hasConceptScore W1995952010C2994232697 @default.
- W1995952010 hasConceptScore W1995952010C42219234 @default.
- W1995952010 hasConceptScore W1995952010C71924100 @default.
- W1995952010 hasConceptScore W1995952010C98274493 @default.
- W1995952010 hasIssue "2" @default.
- W1995952010 hasLocation W19959520101 @default.
- W1995952010 hasLocation W19959520102 @default.
- W1995952010 hasOpenAccess W1995952010 @default.
- W1995952010 hasPrimaryLocation W19959520101 @default.
- W1995952010 hasRelatedWork W1969645821 @default.
- W1995952010 hasRelatedWork W2023619243 @default.
- W1995952010 hasRelatedWork W2045697990 @default.
- W1995952010 hasRelatedWork W2168822023 @default.
- W1995952010 hasRelatedWork W2169562809 @default.
- W1995952010 hasRelatedWork W2415002397 @default.
- W1995952010 hasRelatedWork W2422628669 @default.
- W1995952010 hasRelatedWork W4236345797 @default.
- W1995952010 hasRelatedWork W1785141706 @default.
- W1995952010 hasRelatedWork W2027795091 @default.
- W1995952010 hasVolume "75" @default.
- W1995952010 isParatext "false" @default.
- W1995952010 isRetracted "false" @default.
- W1995952010 magId "1995952010" @default.
- W1995952010 workType "article" @default.