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• W1995953418 abstract "Helper T cells are involved in the pathophysiologic condition of asthma, so modulation of cytokine production may be effective therapy.We aimed to selectively control the synthesis of IL-5 by helper T cells and tested in vivo effects using a murine asthma model.The effect of dexamethasone, FK506, cyclosporin A, and nonactin (a macrolide compound produced by Streptomyces griseus) on cytokine production by allergen-specific T-cell clones was determined. The effect of these agents and an anti-IL-5 neutralizing antibody on airway eosinophilic inflammation was investigated in a murine asthma model.Dexamethasone, FK506, and cyclosporin A suppressed the production of IL-2, IL-4, and IL-5 by human helper T cells, which shows a similar concentration-response relationship in each case. Cyclosporin A and dexamethasone inhibited airway eosinophilia in vivo. Nonactin suppressed IL-5 synthesis but not IL-2 or IL-4 synthesis, and it also significantly suppressed airway eosinophilia.Nonactin only suppressed IL-5 synthesis and was as effective against eosinophilia as cyclosporin A and dexa-methasone, which indicates that IL-5 is a reasonable therapeutic target in allergic disorders that are accompanied by eosinophilic inflammation." @default.
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• W1995953418 date "2000-07-01" @default.
• W1995953418 modified "2023-10-01" @default.
• W1995953418 title "Control of IL-5 production by human helper T cells as a treatment for eosinophilic inflammation: Comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors" @default.
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• W1995953418 doi "https://doi.org/10.1067/mai.2000.106775" @default.
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