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- W1995965022 abstract "Brief exposure to −G z (“push”) reduces eye-level blood pressure (elbp) during subsequent exposure to +G z (“pull”). This is called the “push-pull effect.” To evaluate the influence of gender and the axis of rotation (pitch vs. roll) on the push-pull effect, 10 isoflurane-anesthetized male and 10 female Sprague-Dawley rats were restrained supine on a heated tilt board. Rats were subjected to two G profiles: a control profile consisting of rotation from 0 G z to 90° head-up tilt (+1 G z ) for 10 s and a push-pull profile consisting of rotation from 0 G z to 90° head-down tilt (−1 G z ) for 2 s immediately preceding 10 s of +1 G z stress. A total of 16 tilts consisting of equal numbers of control and push-pull trials and equal numbers of pitch and roll rotations were imposed by using a counterbalanced design. Gender exerted a significant effect on baseline (0 G z ) ELBP (pressure was ∼4 mmHg higher in females). In males and females, ELBP rose to a similar extent (∼8 mmHg) during push, fell to a similar extent (∼18 mmHg) during control +G z stress, and fell to a similar extent (∼22 mmHg) during push-pull +G z stress. Altering the axis of rotation between the x-axis (roll) and the y-axis (pitch) did not influence the results. Thus males and females exhibit a push-pull effect; however, gender and axis of rotation do not appear to influence the push-pull effect in anesthetized rats subjected to tilting." @default.
- W1995965022 created "2016-06-24" @default.
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- W1995965022 date "2002-12-01" @default.
- W1995965022 modified "2023-09-26" @default.
- W1995965022 title "Male and female rats express similar blood pressure responses to “push-pull” gravitational stress" @default.
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- W1995965022 doi "https://doi.org/10.1152/japplphysiol.00179.2002" @default.
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