FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995966536> ?p ?o ?g. }

• W1995966536 endingPage "555" @default.
• W1995966536 startingPage "545" @default.
• W1995966536 abstract "Hemin is present in intracranial hematomas in high micromolar concentrations and is a potent, lipophilic oxidant. Growing evidence suggests that heme-mediated injury may contribute to the pathogenesis of CNS hemorrhage. Extracellular signal-regulated kinases (ERKs) are activated by oxidants in some cell types, and may alter cellular vulnerability to oxidative stress. In this study, the effect of hemin on ERK activation was investigated in cultured murine cortical astrocytes, and the consequence of this activation on cell viability was quantified. Hemin was rapidly taken up by astrocytes, and generated reactive oxygen species (ROS) within 30 min. Increased immunoreactivity of dually phosphorylated ERK1/2 was observed in hemin-treated cultures at 30-120 min, without change in total ERK. Surprisingly, ERK activation was not attenuated by concomitant treatment with antioxidants (U74500A or 1,10-phenanthroline) at concentrations that blocked ROS generation. Cell death commenced after 2 h of hemin exposure and was reduced by antioxidants and by the caspase inhibitor Z-VAD-FMK. Cytotoxicity was also attenuated by MEK inhibition with PD98059 or U0126 at concentrations that were sufficient to prevent ERK activation. Whereas the effect of Z-VAD-FMK on cell survival was transient, the effect of MEK inhibitors was long-lasting. MEK inhibitors had no effect on cellular hemin uptake or subsequent ROS generation. The present results suggest that hemin activates ERK in astrocytes via a mechanism that is independent of ROS generation. This activation sensitizes astrocytes to hemin-mediated oxidative injury." @default.
• W1995966536 created "2016-06-24" @default.
• W1995966536 creator A5022914274 @default.
• W1995966536 creator A5034877267 @default.
• W1995966536 creator A5057204508 @default.
• W1995966536 creator A5075263470 @default.
• W1995966536 creator A5089696151 @default.
• W1995966536 date "2008-07-07" @default.
• W1995966536 modified "2023-10-16" @default.
• W1995966536 title "Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures" @default.
• W1995966536 cites W1495804697 @default.
• W1995966536 cites W1513828871 @default.
• W1995966536 cites W1515063177 @default.
• W1995966536 cites W1527947633 @default.
• W1995966536 cites W1621595817 @default.
• W1995966536 cites W1691996697 @default.
• W1995966536 cites W1811191752 @default.
• W1995966536 cites W1909841186 @default.
• W1995966536 cites W1957958801 @default.
• W1995966536 cites W1967175474 @default.
• W1995966536 cites W1976385326 @default.
• W1995966536 cites W1987790381 @default.
• W1995966536 cites W1988264669 @default.
• W1995966536 cites W1995819749 @default.
• W1995966536 cites W2005558408 @default.
• W1995966536 cites W2011776951 @default.
• W1995966536 cites W2012485229 @default.
• W1995966536 cites W2027349962 @default.
• W1995966536 cites W2028734495 @default.
• W1995966536 cites W2033800625 @default.
• W1995966536 cites W2035936653 @default.
• W1995966536 cites W2038650665 @default.
• W1995966536 cites W2038943408 @default.
• W1995966536 cites W2041403790 @default.
• W1995966536 cites W2043033966 @default.
• W1995966536 cites W2044122230 @default.
• W1995966536 cites W2046938783 @default.
• W1995966536 cites W2054179928 @default.
• W1995966536 cites W2056905161 @default.
• W1995966536 cites W2067524077 @default.
• W1995966536 cites W2076741305 @default.
• W1995966536 cites W2086262311 @default.
• W1995966536 cites W2093050671 @default.
• W1995966536 cites W2110402980 @default.
• W1995966536 cites W2112016771 @default.
• W1995966536 cites W2120324273 @default.
• W1995966536 cites W2128245496 @default.
• W1995966536 cites W2135250775 @default.
• W1995966536 cites W2136547378 @default.
• W1995966536 cites W2142800498 @default.
• W1995966536 cites W2147357406 @default.
• W1995966536 cites W2148091009 @default.
• W1995966536 cites W2161686109 @default.
• W1995966536 cites W2166218864 @default.
• W1995966536 cites W2344992701 @default.
• W1995966536 cites W4230147047 @default.
• W1995966536 doi "https://doi.org/10.1046/j.1471-4159.2001.00590.x" @default.
• W1995966536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11701758" @default.
• W1995966536 hasPublicationYear "2008" @default.
• W1995966536 type Work @default.
• W1995966536 sameAs 1995966536 @default.
• W1995966536 citedByCount "53" @default.
• W1995966536 countsByYear W19959665362012 @default.
• W1995966536 countsByYear W19959665362013 @default.
• W1995966536 countsByYear W19959665362014 @default.
• W1995966536 countsByYear W19959665362015 @default.
• W1995966536 countsByYear W19959665362017 @default.
• W1995966536 countsByYear W19959665362018 @default.
• W1995966536 countsByYear W19959665362019 @default.
• W1995966536 countsByYear W19959665362020 @default.
• W1995966536 countsByYear W19959665362023 @default.
• W1995966536 crossrefType "journal-article" @default.
• W1995966536 hasAuthorship W1995966536A5022914274 @default.
• W1995966536 hasAuthorship W1995966536A5034877267 @default.
• W1995966536 hasAuthorship W1995966536A5057204508 @default.
• W1995966536 hasAuthorship W1995966536A5075263470 @default.
• W1995966536 hasAuthorship W1995966536A5089696151 @default.
• W1995966536 hasConcept C134018914 @default.
• W1995966536 hasConcept C181199279 @default.
• W1995966536 hasConcept C184235292 @default.
• W1995966536 hasConcept C185592680 @default.
• W1995966536 hasConcept C190283241 @default.
• W1995966536 hasConcept C2776151105 @default.
• W1995966536 hasConcept C2776217839 @default.
• W1995966536 hasConcept C2777542381 @default.
• W1995966536 hasConcept C2777723881 @default.
• W1995966536 hasConcept C28406088 @default.
• W1995966536 hasConcept C31573885 @default.
• W1995966536 hasConcept C48349386 @default.
• W1995966536 hasConcept C529278444 @default.
• W1995966536 hasConcept C53227056 @default.
• W1995966536 hasConcept C55493867 @default.
• W1995966536 hasConcept C57074206 @default.
• W1995966536 hasConcept C86803240 @default.
• W1995966536 hasConcept C95444343 @default.
• W1995966536 hasConcept C98274493 @default.
• W1995966536 hasConceptScore W1995966536C134018914 @default.
• W1995966536 hasConceptScore W1995966536C181199279 @default.

• next