Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995969368> ?p ?o ?g. }
- W1995969368 endingPage "1217" @default.
- W1995969368 startingPage "1201" @default.
- W1995969368 abstract "The myelodysplastic syndromes represent a preleukaemic state in which a clonal abnormality of haemopoietic stem cell is characterised by a variety of phenotypic manifestations with varying degrees of ineffective haemopoiesis. This state probably develops as a sequence of events in which the earliest stages may be difficult to detect by conventional pathological techniques. The process is characterised by genetic changes leading to abnormal control of cell proliferation and differentiation. Expansion of an abnormal clone may be related to independence from normal growth factors, insensitivity to normal inhibitory factors, suppression of normal clonal growth, or changes in the immunological or nutritional condition of the host. The haematological picture is of peripheral blood cytopenias: a cellular bone marrow, and functional abnormalities of erythroid, myeloid, and megakaryocytic cells. In most cases marrow cells have an abnormal DNA content, often with disturbances of the cell cycle: an abnormal karyotype is common in premalignant clones. Growth abnormalities of erythroid or granulocyte-macrophage progenitors are common in marrow cultures, and lineage specific surface membrane markers indicate aberrations of differentiation. Progression of the disorder may occur through clonal expansion or through clonal evolution with a greater degree of malignancy. Current attempts to influence abnormal growth and differentiation have had only limited success. Clinical recognition of the syndrome depends on an acute awareness of the signs combined with the identification of clonal and functional abnormalities." @default.
- W1995969368 created "2016-06-24" @default.
- W1995969368 creator A5028410044 @default.
- W1995969368 date "1985-11-01" @default.
- W1995969368 modified "2023-09-27" @default.
- W1995969368 title "Myelodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications." @default.
- W1995969368 cites W147454428 @default.
- W1995969368 cites W1480768564 @default.
- W1995969368 cites W1481581854 @default.
- W1995969368 cites W1484360 @default.
- W1995969368 cites W1504611261 @default.
- W1995969368 cites W1521909328 @default.
- W1995969368 cites W1532449068 @default.
- W1995969368 cites W1533534848 @default.
- W1995969368 cites W1541636956 @default.
- W1995969368 cites W1545630119 @default.
- W1995969368 cites W1549484794 @default.
- W1995969368 cites W1550405405 @default.
- W1995969368 cites W1573337388 @default.
- W1995969368 cites W1591832627 @default.
- W1995969368 cites W1595623280 @default.
- W1995969368 cites W168630383 @default.
- W1995969368 cites W1719540238 @default.
- W1995969368 cites W1748624304 @default.
- W1995969368 cites W1838703570 @default.
- W1995969368 cites W1861931926 @default.
- W1995969368 cites W1861988602 @default.
- W1995969368 cites W189083547 @default.
- W1995969368 cites W1906047018 @default.
- W1995969368 cites W1908327267 @default.
- W1995969368 cites W1964237030 @default.
- W1995969368 cites W1965652568 @default.
- W1995969368 cites W1968374691 @default.
- W1995969368 cites W1968502205 @default.
- W1995969368 cites W1968513860 @default.
- W1995969368 cites W1968990741 @default.
- W1995969368 cites W1970879779 @default.
- W1995969368 cites W1971562349 @default.
- W1995969368 cites W1971758557 @default.
- W1995969368 cites W1973644288 @default.
- W1995969368 cites W1976245365 @default.
- W1995969368 cites W1977880082 @default.
- W1995969368 cites W1978044296 @default.
- W1995969368 cites W1978701554 @default.
- W1995969368 cites W1978895885 @default.
- W1995969368 cites W1980008992 @default.
- W1995969368 cites W1980147439 @default.
- W1995969368 cites W1980546569 @default.
- W1995969368 cites W1982020713 @default.
- W1995969368 cites W1983068803 @default.
- W1995969368 cites W1986987869 @default.
- W1995969368 cites W1987589890 @default.
- W1995969368 cites W1988377432 @default.
- W1995969368 cites W1989009382 @default.
- W1995969368 cites W1989281816 @default.
- W1995969368 cites W1990231489 @default.
- W1995969368 cites W1991090636 @default.
- W1995969368 cites W1991116274 @default.
- W1995969368 cites W1991569222 @default.
- W1995969368 cites W1994806744 @default.
- W1995969368 cites W1996305626 @default.
- W1995969368 cites W1996406158 @default.
- W1995969368 cites W1999001731 @default.
- W1995969368 cites W200132638 @default.
- W1995969368 cites W2002611329 @default.
- W1995969368 cites W2007518731 @default.
- W1995969368 cites W2008835549 @default.
- W1995969368 cites W2010621620 @default.
- W1995969368 cites W2011331626 @default.
- W1995969368 cites W2012463184 @default.
- W1995969368 cites W2012511385 @default.
- W1995969368 cites W2012571603 @default.
- W1995969368 cites W2012850212 @default.
- W1995969368 cites W2012883868 @default.
- W1995969368 cites W2013135996 @default.
- W1995969368 cites W2013232197 @default.
- W1995969368 cites W2013554303 @default.
- W1995969368 cites W2014705527 @default.
- W1995969368 cites W2015627245 @default.
- W1995969368 cites W2016568386 @default.
- W1995969368 cites W2017282278 @default.
- W1995969368 cites W2018535264 @default.
- W1995969368 cites W2019349530 @default.
- W1995969368 cites W2021253208 @default.
- W1995969368 cites W2021622918 @default.
- W1995969368 cites W2022106508 @default.
- W1995969368 cites W2022525159 @default.
- W1995969368 cites W2023965839 @default.
- W1995969368 cites W2025529909 @default.
- W1995969368 cites W2027888524 @default.
- W1995969368 cites W2030783291 @default.
- W1995969368 cites W2030924173 @default.
- W1995969368 cites W2031185707 @default.
- W1995969368 cites W2032502279 @default.
- W1995969368 cites W2033172039 @default.
- W1995969368 cites W2034185792 @default.
- W1995969368 cites W2035424128 @default.
- W1995969368 cites W2035882113 @default.