Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995976919> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1995976919 abstract "In view of the potential role of prostaglandins (PGs) in development of glomerular hyperfiltration leading to diabetic nephropathy, we studied the temporal relationship of the activity of cytosolic phospholipase A2 (cPLA2), a rate-limiting enzyme for eicosanoid biosynthesis, with hyperfiltration and the histological changes in glomeruli using OLETF rats, a model for non-insulin-dependent diabetes mellitus (NIDDM). Diabetes mellitus and associated histopathological changes, which developed spontaneously by 30-46 weeks after birth of OLETF rats, were accompanied by approximately 65% increase in glomerular cPLA2 activity that showed significant correlations with elevated plasma glucose levels and creatinine clearance. Moreover, mesangial cells cultured for 5 days with high glucose exhibited approximately 2-fold higher cPLA2 activity than those cultured with physiologic level of glucose. These data suggest that increased glomerular cPLA2 activity leads to production of PGs, which may promote the progression of early diabetic glomerular hyperfiltration and subsequent diabetic nephropathy." @default.
- W1995976919 created "2016-06-24" @default.
- W1995976919 creator A5005413756 @default.
- W1995976919 creator A5011601287 @default.
- W1995976919 creator A5012938588 @default.
- W1995976919 creator A5018240575 @default.
- W1995976919 creator A5019195799 @default.
- W1995976919 creator A5032260297 @default.
- W1995976919 creator A5037349557 @default.
- W1995976919 creator A5037780357 @default.
- W1995976919 creator A5043353526 @default.
- W1995976919 creator A5043688508 @default.
- W1995976919 creator A5055493310 @default.
- W1995976919 creator A5086587001 @default.
- W1995976919 date "2009-07-14" @default.
- W1995976919 modified "2023-09-25" @default.
- W1995976919 title "Increased glomerular cytosolic phospholipase A2 activity of OLETF rats with early diabetes" @default.
- W1995976919 doi "https://doi.org/10.1055/s-0029-1212116" @default.
- W1995976919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10482042" @default.
- W1995976919 hasPublicationYear "2009" @default.
- W1995976919 type Work @default.
- W1995976919 sameAs 1995976919 @default.
- W1995976919 citedByCount "10" @default.
- W1995976919 countsByYear W19959769192015 @default.
- W1995976919 countsByYear W19959769192018 @default.
- W1995976919 crossrefType "journal-article" @default.
- W1995976919 hasAuthorship W1995976919A5005413756 @default.
- W1995976919 hasAuthorship W1995976919A5011601287 @default.
- W1995976919 hasAuthorship W1995976919A5012938588 @default.
- W1995976919 hasAuthorship W1995976919A5018240575 @default.
- W1995976919 hasAuthorship W1995976919A5019195799 @default.
- W1995976919 hasAuthorship W1995976919A5032260297 @default.
- W1995976919 hasAuthorship W1995976919A5037349557 @default.
- W1995976919 hasAuthorship W1995976919A5037780357 @default.
- W1995976919 hasAuthorship W1995976919A5043353526 @default.
- W1995976919 hasAuthorship W1995976919A5043688508 @default.
- W1995976919 hasAuthorship W1995976919A5055493310 @default.
- W1995976919 hasAuthorship W1995976919A5086587001 @default.
- W1995976919 hasConcept C126322002 @default.
- W1995976919 hasConcept C134018914 @default.
- W1995976919 hasConcept C159641895 @default.
- W1995976919 hasConcept C2776179406 @default.
- W1995976919 hasConcept C2779922275 @default.
- W1995976919 hasConcept C2781184683 @default.
- W1995976919 hasConcept C555293320 @default.
- W1995976919 hasConcept C71924100 @default.
- W1995976919 hasConceptScore W1995976919C126322002 @default.
- W1995976919 hasConceptScore W1995976919C134018914 @default.
- W1995976919 hasConceptScore W1995976919C159641895 @default.
- W1995976919 hasConceptScore W1995976919C2776179406 @default.
- W1995976919 hasConceptScore W1995976919C2779922275 @default.
- W1995976919 hasConceptScore W1995976919C2781184683 @default.
- W1995976919 hasConceptScore W1995976919C555293320 @default.
- W1995976919 hasConceptScore W1995976919C71924100 @default.
- W1995976919 hasLocation W19959769191 @default.
- W1995976919 hasLocation W19959769192 @default.
- W1995976919 hasOpenAccess W1995976919 @default.
- W1995976919 hasPrimaryLocation W19959769191 @default.
- W1995976919 hasRelatedWork W1979228623 @default.
- W1995976919 hasRelatedWork W1985345175 @default.
- W1995976919 hasRelatedWork W1996393091 @default.
- W1995976919 hasRelatedWork W1998899029 @default.
- W1995976919 hasRelatedWork W2003285053 @default.
- W1995976919 hasRelatedWork W2012797973 @default.
- W1995976919 hasRelatedWork W2024229249 @default.
- W1995976919 hasRelatedWork W2044283979 @default.
- W1995976919 hasRelatedWork W2048191010 @default.
- W1995976919 hasRelatedWork W2072437489 @default.
- W1995976919 hasRelatedWork W2077798045 @default.
- W1995976919 hasRelatedWork W2078083049 @default.
- W1995976919 hasRelatedWork W2102615311 @default.
- W1995976919 hasRelatedWork W2117060894 @default.
- W1995976919 hasRelatedWork W2143450763 @default.
- W1995976919 hasRelatedWork W2146385654 @default.
- W1995976919 hasRelatedWork W2161422560 @default.
- W1995976919 hasRelatedWork W2167092770 @default.
- W1995976919 hasRelatedWork W2350113597 @default.
- W1995976919 hasRelatedWork W2419054756 @default.
- W1995976919 isParatext "false" @default.
- W1995976919 isRetracted "false" @default.
- W1995976919 magId "1995976919" @default.
- W1995976919 workType "article" @default.