FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995982458> ?p ?o ?g. }

• W1995982458 endingPage "621" @default.
• W1995982458 startingPage "609" @default.
• W1995982458 abstract "Resistance to thyroid hormone (RTH) is characterized by elevated serum thyroid hormones, failure to suppress pituitary TSH secretion, and variable T3 responsiveness in peripheral tissues. The disorder is associated with diverse mutations that cluster within three areas of the thyroid hormone beta(TR beta) receptor. Here, we report a novel RTH mutation (R383H), which is located in a region not known to harbor naturally occurring mutations. Although the R383H mutant receptor activated positively regulated genes to an extent comparable to wild-type (WT), negative transcriptional regulation of human TSH alpha and TRH promoters was impaired in either TR beta 1 or TR beta 2 contexts, and WT receptor function was dominantly inhibited. T3-dependent changes in basal transcription with R383H were also impaired: on the TRH promoter, basal activation by unliganded R383H was not reversed by T3 to the same extent as WT; similarly transcriptional silencing by an unliganded Gal4-R383H fusion was not relieved at a T3 concentration that derepressed WT. In keeping with this, ligand-dependent corepressor release by R383H, either in a protein-protein interaction assay or as a DNA-bound heterodimer with retinoid X receptor on either positive or negative thyroid hormone response elements, was disproportionately impaired relative to its ligand-binding affinity, whereas its T3-dependent recruitment of coactivator was unimpaired. These properties were shared by another previously described RTH mutant (R429Q), and in the crystal structure of TR alpha the homologous residues interact in a polar invagination. Our data indicate a role for these residues in mediating negative transcriptional regulation and facilitating corepressor release and suggest that predominant impairment of these functions may be the minimal requirements for causation of RTH." @default.
• W1995982458 created "2016-06-24" @default.
• W1995982458 creator A5007328188 @default.
• W1995982458 creator A5007357943 @default.
• W1995982458 creator A5019367442 @default.
• W1995982458 creator A5048710646 @default.
• W1995982458 creator A5065094989 @default.
• W1995982458 creator A5066999906 @default.
• W1995982458 creator A5069720615 @default.
• W1995982458 creator A5071736938 @default.
• W1995982458 date "1998-05-01" @default.
• W1995982458 modified "2023-10-15" @default.
• W1995982458 title "A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional Regulation" @default.
• W1995982458 cites W1501286679 @default.
• W1995982458 cites W1602722523 @default.
• W1995982458 cites W1613446635 @default.
• W1995982458 cites W1649701723 @default.
• W1995982458 cites W1678512432 @default.
• W1995982458 cites W1965202057 @default.
• W1995982458 cites W1966896695 @default.
• W1995982458 cites W1971032700 @default.
• W1995982458 cites W1985063313 @default.
• W1995982458 cites W1988179233 @default.
• W1995982458 cites W1990406294 @default.
• W1995982458 cites W1990613292 @default.
• W1995982458 cites W1990939350 @default.
• W1995982458 cites W1991855634 @default.
• W1995982458 cites W1997873916 @default.
• W1995982458 cites W2004988279 @default.
• W1995982458 cites W2005531918 @default.
• W1995982458 cites W2005923965 @default.
• W1995982458 cites W2013378362 @default.
• W1995982458 cites W2026441085 @default.
• W1995982458 cites W2027847404 @default.
• W1995982458 cites W2029156328 @default.
• W1995982458 cites W2031952810 @default.
• W1995982458 cites W2033529039 @default.
• W1995982458 cites W2034266830 @default.
• W1995982458 cites W2036639816 @default.
• W1995982458 cites W2056724579 @default.
• W1995982458 cites W2060478264 @default.
• W1995982458 cites W2063295358 @default.
• W1995982458 cites W2063679634 @default.
• W1995982458 cites W2068113812 @default.
• W1995982458 cites W2068733538 @default.
• W1995982458 cites W2069532898 @default.
• W1995982458 cites W2077580619 @default.
• W1995982458 cites W2077975462 @default.
• W1995982458 cites W2085124463 @default.
• W1995982458 cites W2085997746 @default.
• W1995982458 cites W2086369556 @default.
• W1995982458 cites W2095145439 @default.
• W1995982458 cites W2105940645 @default.
• W1995982458 cites W2107695708 @default.
• W1995982458 cites W2117327443 @default.
• W1995982458 cites W2123643321 @default.
• W1995982458 cites W2132933799 @default.
• W1995982458 cites W2134461114 @default.
• W1995982458 cites W2143241514 @default.
• W1995982458 cites W2145221641 @default.
• W1995982458 cites W2150435178 @default.
• W1995982458 cites W2152355177 @default.
• W1995982458 cites W2162702340 @default.
• W1995982458 cites W2163188040 @default.
• W1995982458 cites W3144646952 @default.
• W1995982458 doi "https://doi.org/10.1210/mend.12.5.0113" @default.
• W1995982458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9605924" @default.
• W1995982458 hasPublicationYear "1998" @default.
• W1995982458 type Work @default.
• W1995982458 sameAs 1995982458 @default.
• W1995982458 citedByCount "25" @default.
• W1995982458 countsByYear W19959824582015 @default.
• W1995982458 countsByYear W19959824582017 @default.
• W1995982458 countsByYear W19959824582019 @default.
• W1995982458 countsByYear W19959824582021 @default.
• W1995982458 crossrefType "journal-article" @default.
• W1995982458 hasAuthorship W1995982458A5007328188 @default.
• W1995982458 hasAuthorship W1995982458A5007357943 @default.
• W1995982458 hasAuthorship W1995982458A5019367442 @default.
• W1995982458 hasAuthorship W1995982458A5048710646 @default.
• W1995982458 hasAuthorship W1995982458A5065094989 @default.
• W1995982458 hasAuthorship W1995982458A5066999906 @default.
• W1995982458 hasAuthorship W1995982458A5069720615 @default.
• W1995982458 hasAuthorship W1995982458A5071736938 @default.
• W1995982458 hasBestOaLocation W19959824581 @default.
• W1995982458 hasConcept C104317684 @default.
• W1995982458 hasConcept C109115496 @default.
• W1995982458 hasConcept C121608353 @default.
• W1995982458 hasConcept C126322002 @default.
• W1995982458 hasConcept C134018914 @default.
• W1995982458 hasConcept C146777309 @default.
• W1995982458 hasConcept C149574134 @default.
• W1995982458 hasConcept C153911025 @default.
• W1995982458 hasConcept C158448853 @default.
• W1995982458 hasConcept C160860887 @default.
• W1995982458 hasConcept C23589133 @default.
• W1995982458 hasConcept C526584372 @default.
• W1995982458 hasConcept C530470458 @default.

• next