FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995985042> ?p ?o ?g. }

• W1995985042 endingPage "170" @default.
• W1995985042 startingPage "163" @default.
• W1995985042 abstract "The thioredoxin-like activity of human follicle stimulating hormone (hFSH), hFSH-beta-(83-88) peptide amide (hFSH-beta-(83-88) which has a sequence similar to the thioredoxin active center (-His-Cys-Gly-Lys-Cys-Asp-)) and thioredoxin-(31-36)-peptide amide (TD-(31-36) which contains the redox-active dithiol of thioredoxin (-Trp-Cys-Gly-Pro-Cys-Lys-)) was characterized by their ability to reactivate reduced and denatured bovine pancreatic ribonuclease (RNase). This assay reflects the recently recognized ability of thioredoxin to catalyze disulfide bond formation in proteins. Compared to uncatalyzed refolding of reduced, denatured substrate, hFSH was approximately 10-fold more active than thioredoxin on a molar basis. The catalytic activity of hFSH-beta-(83-88) and TD-(31-36) was equivalent to that of an equimolar concentration of thioredoxin. Screening of 11 overlapping peptide amides representing the entire primary structure of hFSH-beta-subunit indicated that hFSH-beta-(81-95), which contains the sequence similar to the thioredoxin active center within a receptor-binding region of the hFSH-beta-subunit, possesses strong thioredoxin-like activity and was more active than an equimolar concentration of thioredoxin. In contrast, hFSH-beta-(33-53), a thiol-containing peptide which corresponds to a second FSH receptor-binding domain but lacks the sequence similar to the thioredoxin active center, was inactive. Synthetic peptide amides corresponding to other regions of hFSH-beta-subunit were less effective than hFSH-beta-(81-95) in reactivating reduced and denatured RNase. Our data provide evidence that the recently reported thioredoxin-like catalytic activity of FSH may be due, at least in part, to the redox-active dithiol present within a receptor-binding domain of its beta-subunit, and thus may have a physiological role in receptor binding or signal transduction." @default.
• W1995985042 created "2016-06-24" @default.
• W1995985042 creator A5023843257 @default.
• W1995985042 creator A5035022243 @default.
• W1995985042 creator A5052850202 @default.
• W1995985042 creator A5070752219 @default.
• W1995985042 date "1991-07-01" @default.
• W1995985042 modified "2023-09-23" @default.
• W1995985042 title "A synthetic peptide corresponding to hFSH-β-(81–95) has thioredoxin-like activity" @default.
• W1995985042 cites W1525120405 @default.
• W1995985042 cites W1526839960 @default.
• W1995985042 cites W1551150032 @default.
• W1995985042 cites W1568046905 @default.
• W1995985042 cites W1568856980 @default.
• W1995985042 cites W1595838029 @default.
• W1995985042 cites W1788190869 @default.
• W1995985042 cites W1955101318 @default.
• W1995985042 cites W1966349832 @default.
• W1995985042 cites W1967647423 @default.
• W1995985042 cites W1975304761 @default.
• W1995985042 cites W1982835546 @default.
• W1995985042 cites W1988865472 @default.
• W1995985042 cites W1988952372 @default.
• W1995985042 cites W2007673454 @default.
• W1995985042 cites W2009310436 @default.
• W1995985042 cites W2009946840 @default.
• W1995985042 cites W2027333557 @default.
• W1995985042 cites W2043025348 @default.
• W1995985042 cites W2059665365 @default.
• W1995985042 cites W2062524176 @default.
• W1995985042 cites W2064693361 @default.
• W1995985042 cites W2074779525 @default.
• W1995985042 cites W2087202599 @default.
• W1995985042 cites W2091082518 @default.
• W1995985042 cites W2092292088 @default.
• W1995985042 cites W2095450147 @default.
• W1995985042 cites W2098078154 @default.
• W1995985042 cites W2152614869 @default.
• W1995985042 cites W2269862327 @default.
• W1995985042 cites W2320556745 @default.
• W1995985042 cites W4244235091 @default.
• W1995985042 cites W4247896860 @default.
• W1995985042 doi "https://doi.org/10.1016/0303-7207(91)90119-d" @default.
• W1995985042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1778302" @default.
• W1995985042 hasPublicationYear "1991" @default.
• W1995985042 type Work @default.
• W1995985042 sameAs 1995985042 @default.
• W1995985042 citedByCount "14" @default.
• W1995985042 countsByYear W19959850422018 @default.
• W1995985042 countsByYear W19959850422022 @default.
• W1995985042 crossrefType "journal-article" @default.
• W1995985042 hasAuthorship W1995985042A5023843257 @default.
• W1995985042 hasAuthorship W1995985042A5035022243 @default.
• W1995985042 hasAuthorship W1995985042A5052850202 @default.
• W1995985042 hasAuthorship W1995985042A5070752219 @default.
• W1995985042 hasConcept C104292427 @default.
• W1995985042 hasConcept C104317684 @default.
• W1995985042 hasConcept C10879258 @default.
• W1995985042 hasConcept C134621786 @default.
• W1995985042 hasConcept C167625842 @default.
• W1995985042 hasConcept C181199279 @default.
• W1995985042 hasConcept C185592680 @default.
• W1995985042 hasConcept C2776813977 @default.
• W1995985042 hasConcept C2777737464 @default.
• W1995985042 hasConcept C2777824588 @default.
• W1995985042 hasConcept C2778976237 @default.
• W1995985042 hasConcept C2779281246 @default.
• W1995985042 hasConcept C3623737 @default.
• W1995985042 hasConcept C41183919 @default.
• W1995985042 hasConcept C55493867 @default.
• W1995985042 hasConcept C67705224 @default.
• W1995985042 hasConcept C70412867 @default.
• W1995985042 hasConcept C86803240 @default.
• W1995985042 hasConceptScore W1995985042C104292427 @default.
• W1995985042 hasConceptScore W1995985042C104317684 @default.
• W1995985042 hasConceptScore W1995985042C10879258 @default.
• W1995985042 hasConceptScore W1995985042C134621786 @default.
• W1995985042 hasConceptScore W1995985042C167625842 @default.
• W1995985042 hasConceptScore W1995985042C181199279 @default.
• W1995985042 hasConceptScore W1995985042C185592680 @default.
• W1995985042 hasConceptScore W1995985042C2776813977 @default.
• W1995985042 hasConceptScore W1995985042C2777737464 @default.
• W1995985042 hasConceptScore W1995985042C2777824588 @default.
• W1995985042 hasConceptScore W1995985042C2778976237 @default.
• W1995985042 hasConceptScore W1995985042C2779281246 @default.
• W1995985042 hasConceptScore W1995985042C3623737 @default.
• W1995985042 hasConceptScore W1995985042C41183919 @default.
• W1995985042 hasConceptScore W1995985042C55493867 @default.
• W1995985042 hasConceptScore W1995985042C67705224 @default.
• W1995985042 hasConceptScore W1995985042C70412867 @default.
• W1995985042 hasConceptScore W1995985042C86803240 @default.
• W1995985042 hasIssue "3" @default.
• W1995985042 hasLocation W19959850421 @default.
• W1995985042 hasLocation W19959850422 @default.
• W1995985042 hasOpenAccess W1995985042 @default.
• W1995985042 hasPrimaryLocation W19959850421 @default.
• W1995985042 hasRelatedWork W1651208294 @default.
• W1995985042 hasRelatedWork W1966496559 @default.

• next