FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995990320> ?p ?o ?g. }

• W1995990320 endingPage "77" @default.
• W1995990320 startingPage "71" @default.
• W1995990320 abstract "To determine whether glucose utilization and metabolic substrate (glucose and fat) oxidation could be manipulated in patients with secondary multiple organ dysfunction syndrome.Prospective study.Intensive care units (ICU) of two university hospitals.Eight adults free of hepatic disease and hemodynamically stable at the time of study, but with failed respiratory and gastrointestinal systems, who thus required mechanical ventilation and intravenous nutrition.Patients were infused with 20% dextrose through central venous cannulas at rates that increased and maintained (clamped) their plasma glucose concentration at 216 mg/dL (12 mmol/L) for 3 hrs. Somatostatin was infused continuously during the second and third hours of the clamp to reduce plasma concentrations of endogenous insulin and glucagon. Exogenous insulin was administered together with somatostatin during the third hour to restore basal insulin concentrations. Energy expenditure was measured by indirect calorimetry throughout the study and blood samples were withdrawn regularly for determination of metabolite and hormone concentrations. Main statistical comparisons were made between the baseline data (first hour of the study) and data collected during the second and third hours of the clamp.Plasma glucagon concentrations were reduced by nearly 50% (p < .05) toward the end of the study, whereas no significant changes in plasma concentrations of cortisol or growth hormone occurred. Energy expenditure did not change significantly at any time during the clamp procedure. Glucose utilization (6.1 mg/kg/min [34 mumol/kg/min]) during the first hour of the hyperglycemic clamp, decreased by 53% (p < .05) with the infusion of somatostatin during the second hour of the clamp. However, once exogenous insulin was infused during the third hour, glucose utilization increased by 55% (p < .05) when compared with the baseline (hour 1) rate. Glucose oxidation was nearly doubled during the third hour of the study when compared with oxidation rates during the first and second hours. Fat oxidation decreased steadily during the 3-hr clamp.Glucagon has a significant inhibitory effect on glucose utilization during intravenous glucose infusion in the multiple organ dysfunction syndrome patient. Pharmacologic intervention with somatostatin and insulin (physiologic dose) can facilitate glucose utilization and oxidation in these patients. Further investigations are needed to determine whether long-term alteration of glucose and fat metabolism would be beneficial in the patient with secondary multiple organ dysfunction syndrome." @default.
• W1995990320 created "2016-06-24" @default.
• W1995990320 creator A5025633737 @default.
• W1995990320 creator A5041201112 @default.
• W1995990320 creator A5042603933 @default.
• W1995990320 creator A5042874361 @default.
• W1995990320 creator A5044051466 @default.
• W1995990320 creator A5058465672 @default.
• W1995990320 creator A5081396274 @default.
• W1995990320 date "1995-01-01" @default.
• W1995990320 modified "2023-10-16" @default.
• W1995990320 title "Manipulation of substrate utilization with somatostatin in patients with secondary multiple organ dysfunction syndrome" @default.
• W1995990320 cites W1982649623 @default.
• W1995990320 cites W1985645871 @default.
• W1995990320 cites W1993680376 @default.
• W1995990320 cites W1995780597 @default.
• W1995990320 cites W2006208984 @default.
• W1995990320 cites W2018043022 @default.
• W1995990320 cites W2023093347 @default.
• W1995990320 cites W2023725478 @default.
• W1995990320 cites W2024764743 @default.
• W1995990320 cites W2030014624 @default.
• W1995990320 cites W2043275746 @default.
• W1995990320 cites W2063292670 @default.
• W1995990320 cites W2079110701 @default.
• W1995990320 cites W2080355644 @default.
• W1995990320 cites W2082867344 @default.
• W1995990320 cites W2088180294 @default.
• W1995990320 cites W2094625904 @default.
• W1995990320 cites W2131501155 @default.
• W1995990320 cites W2143489286 @default.
• W1995990320 cites W2171654087 @default.
• W1995990320 cites W2302600294 @default.
• W1995990320 cites W4293242440 @default.
• W1995990320 doi "https://doi.org/10.1097/00003246-199501000-00014" @default.
• W1995990320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8001390" @default.
• W1995990320 hasPublicationYear "1995" @default.
• W1995990320 type Work @default.
• W1995990320 sameAs 1995990320 @default.
• W1995990320 citedByCount "9" @default.
• W1995990320 crossrefType "journal-article" @default.
• W1995990320 hasAuthorship W1995990320A5025633737 @default.
• W1995990320 hasAuthorship W1995990320A5041201112 @default.
• W1995990320 hasAuthorship W1995990320A5042603933 @default.
• W1995990320 hasAuthorship W1995990320A5042874361 @default.
• W1995990320 hasAuthorship W1995990320A5044051466 @default.
• W1995990320 hasAuthorship W1995990320A5058465672 @default.
• W1995990320 hasAuthorship W1995990320A5081396274 @default.
• W1995990320 hasConcept C126322002 @default.
• W1995990320 hasConcept C127413603 @default.
• W1995990320 hasConcept C134018914 @default.
• W1995990320 hasConcept C177713679 @default.
• W1995990320 hasConcept C2776161997 @default.
• W1995990320 hasConcept C2776297358 @default.
• W1995990320 hasConcept C2778024521 @default.
• W1995990320 hasConcept C2778563252 @default.
• W1995990320 hasConcept C2779306644 @default.
• W1995990320 hasConcept C2987404301 @default.
• W1995990320 hasConcept C71315377 @default.
• W1995990320 hasConcept C71924100 @default.
• W1995990320 hasConcept C78519656 @default.
• W1995990320 hasConcept C84111939 @default.
• W1995990320 hasConceptScore W1995990320C126322002 @default.
• W1995990320 hasConceptScore W1995990320C127413603 @default.
• W1995990320 hasConceptScore W1995990320C134018914 @default.
• W1995990320 hasConceptScore W1995990320C177713679 @default.
• W1995990320 hasConceptScore W1995990320C2776161997 @default.
• W1995990320 hasConceptScore W1995990320C2776297358 @default.
• W1995990320 hasConceptScore W1995990320C2778024521 @default.
• W1995990320 hasConceptScore W1995990320C2778563252 @default.
• W1995990320 hasConceptScore W1995990320C2779306644 @default.
• W1995990320 hasConceptScore W1995990320C2987404301 @default.
• W1995990320 hasConceptScore W1995990320C71315377 @default.
• W1995990320 hasConceptScore W1995990320C71924100 @default.
• W1995990320 hasConceptScore W1995990320C78519656 @default.
• W1995990320 hasConceptScore W1995990320C84111939 @default.
• W1995990320 hasIssue "1" @default.
• W1995990320 hasLocation W19959903201 @default.
• W1995990320 hasLocation W19959903202 @default.
• W1995990320 hasOpenAccess W1995990320 @default.
• W1995990320 hasPrimaryLocation W19959903201 @default.
• W1995990320 hasRelatedWork W1974106130 @default.
• W1995990320 hasRelatedWork W1993017717 @default.
• W1995990320 hasRelatedWork W2015817662 @default.
• W1995990320 hasRelatedWork W2050730962 @default.
• W1995990320 hasRelatedWork W2068166803 @default.
• W1995990320 hasRelatedWork W2070076315 @default.
• W1995990320 hasRelatedWork W2073369605 @default.
• W1995990320 hasRelatedWork W2084131229 @default.
• W1995990320 hasRelatedWork W2088717006 @default.
• W1995990320 hasRelatedWork W2410469327 @default.
• W1995990320 hasVolume "23" @default.
• W1995990320 isParatext "false" @default.
• W1995990320 isRetracted "false" @default.
• W1995990320 magId "1995990320" @default.
• W1995990320 workType "article" @default.