FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995993143> ?p ?o ?g. }

• W1995993143 endingPage "1339.e2" @default.
• W1995993143 startingPage "1332" @default.
• W1995993143 abstract "ObjectiveWe sought to investigate immune cell kinetics in relation to skeletal myoblast survival and heart function improvement after nonautologous skeletal myoblast transplantation in a rat model of myocardial infarction.MethodsOne week after myocardial infarction, 208 Wistar rats were grouped into group 1 (n = 24, receiving 150 μL of medium only), group 2 (n = 24, receiving 150 μL of medium and cyclosporine [INN: ciclosporin]), group 3 (n = 40, human skeletal myoblast transplantation), group 4 (n = 40, human skeletal myoblast transplantation with cyclosporine treatment), group 5 (n = 40, rat skeletal myoblast transplantation), and group 6 (n = 40, rat skeletal myoblast transplantation with cyclosporine treatment). The hearts were harvested at 10 minutes and 1, 4, 7, and 28 days after cell transplantation. Skeletal myoblast survival was confirmed by means of immunohistochemical studies and quantified by using real-time polymerase chain reaction. Host immune responses were assessed by immunostaining for macrophages and CD4+ and CD8+ lymphocytes. Heart function was evaluated by means of echocardiographic analysis.ResultsThe majority of macrophages and lymphocytes infiltrated in the acute phase (from day 1 to day 7) and then subsided by day 28. The donor skeletal myoblasts survived and differentiated well in all skeletal myoblast transplantation groups. Allogeneic skeletal myoblasts showed a superior survival rate than xenogeneic skeletal myoblasts (P < .01). Cyclosporine inhibited the infiltration of the immunocytes, enhanced skeletal myoblast survival, and improved heart performance compared with that seen in the groups not receiving cyclosporine treatment (P < .05).ConclusionsAllomyoblasts survive better than do xenomyoblasts after transplantation into infarcted myocardium. After inhibition of immunocyte infiltration by means of immunosuppressive treatment, skeletal myoblast survival is enhanced, with improved heart performance. These findings suggest the feasibility of nonautologous myoblast transplantation with immunosuppressive treatment. We sought to investigate immune cell kinetics in relation to skeletal myoblast survival and heart function improvement after nonautologous skeletal myoblast transplantation in a rat model of myocardial infarction. One week after myocardial infarction, 208 Wistar rats were grouped into group 1 (n = 24, receiving 150 μL of medium only), group 2 (n = 24, receiving 150 μL of medium and cyclosporine [INN: ciclosporin]), group 3 (n = 40, human skeletal myoblast transplantation), group 4 (n = 40, human skeletal myoblast transplantation with cyclosporine treatment), group 5 (n = 40, rat skeletal myoblast transplantation), and group 6 (n = 40, rat skeletal myoblast transplantation with cyclosporine treatment). The hearts were harvested at 10 minutes and 1, 4, 7, and 28 days after cell transplantation. Skeletal myoblast survival was confirmed by means of immunohistochemical studies and quantified by using real-time polymerase chain reaction. Host immune responses were assessed by immunostaining for macrophages and CD4+ and CD8+ lymphocytes. Heart function was evaluated by means of echocardiographic analysis. The majority of macrophages and lymphocytes infiltrated in the acute phase (from day 1 to day 7) and then subsided by day 28. The donor skeletal myoblasts survived and differentiated well in all skeletal myoblast transplantation groups. Allogeneic skeletal myoblasts showed a superior survival rate than xenogeneic skeletal myoblasts (P < .01). Cyclosporine inhibited the infiltration of the immunocytes, enhanced skeletal myoblast survival, and improved heart performance compared with that seen in the groups not receiving cyclosporine treatment (P < .05). Allomyoblasts survive better than do xenomyoblasts after transplantation into infarcted myocardium. After inhibition of immunocyte infiltration by means of immunosuppressive treatment, skeletal myoblast survival is enhanced, with improved heart performance. These findings suggest the feasibility of nonautologous myoblast transplantation with immunosuppressive treatment." @default.
• W1995993143 created "2016-06-24" @default.
• W1995993143 creator A5009235853 @default.
• W1995993143 creator A5027649343 @default.
• W1995993143 creator A5032353933 @default.
• W1995993143 creator A5033702023 @default.
• W1995993143 creator A5043017215 @default.
• W1995993143 creator A5059775961 @default.
• W1995993143 creator A5075759170 @default.
• W1995993143 creator A5077578379 @default.
• W1995993143 creator A5090188795 @default.
• W1995993143 date "2007-11-01" @default.
• W1995993143 modified "2023-10-11" @default.
• W1995993143 title "Myoblast-based cardiac repair: Xenomyoblast versus allomyoblast transplantation" @default.
• W1995993143 cites W1606274538 @default.
• W1995993143 cites W1976686248 @default.
• W1995993143 cites W1984550452 @default.
• W1995993143 cites W1986332005 @default.
• W1995993143 cites W1991008729 @default.
• W1995993143 cites W2005016150 @default.
• W1995993143 cites W2016392251 @default.
• W1995993143 cites W2031930422 @default.
• W1995993143 cites W2032921899 @default.
• W1995993143 cites W2036925553 @default.
• W1995993143 cites W2098849525 @default.
• W1995993143 cites W2106764538 @default.
• W1995993143 cites W2109381162 @default.
• W1995993143 cites W2134704099 @default.
• W1995993143 cites W2141381761 @default.
• W1995993143 cites W2144547348 @default.
• W1995993143 cites W2285601132 @default.
• W1995993143 cites W2412365538 @default.
• W1995993143 cites W2418696384 @default.
• W1995993143 cites W2113951771 @default.
• W1995993143 doi "https://doi.org/10.1016/j.jtcvs.2007.07.025" @default.
• W1995993143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17976470" @default.
• W1995993143 hasPublicationYear "2007" @default.
• W1995993143 type Work @default.
• W1995993143 sameAs 1995993143 @default.
• W1995993143 citedByCount "13" @default.
• W1995993143 countsByYear W19959931432013 @default.
• W1995993143 countsByYear W19959931432014 @default.
• W1995993143 countsByYear W19959931432015 @default.
• W1995993143 countsByYear W19959931432016 @default.
• W1995993143 countsByYear W19959931432019 @default.
• W1995993143 crossrefType "journal-article" @default.
• W1995993143 hasAuthorship W1995993143A5009235853 @default.
• W1995993143 hasAuthorship W1995993143A5027649343 @default.
• W1995993143 hasAuthorship W1995993143A5032353933 @default.
• W1995993143 hasAuthorship W1995993143A5033702023 @default.
• W1995993143 hasAuthorship W1995993143A5043017215 @default.
• W1995993143 hasAuthorship W1995993143A5059775961 @default.
• W1995993143 hasAuthorship W1995993143A5075759170 @default.
• W1995993143 hasAuthorship W1995993143A5077578379 @default.
• W1995993143 hasAuthorship W1995993143A5090188795 @default.
• W1995993143 hasBestOaLocation W19959931431 @default.
• W1995993143 hasConcept C126322002 @default.
• W1995993143 hasConcept C204232928 @default.
• W1995993143 hasConcept C207200792 @default.
• W1995993143 hasConcept C2778849806 @default.
• W1995993143 hasConcept C2779959927 @default.
• W1995993143 hasConcept C2911091166 @default.
• W1995993143 hasConcept C4224716 @default.
• W1995993143 hasConcept C71924100 @default.
• W1995993143 hasConceptScore W1995993143C126322002 @default.
• W1995993143 hasConceptScore W1995993143C204232928 @default.
• W1995993143 hasConceptScore W1995993143C207200792 @default.
• W1995993143 hasConceptScore W1995993143C2778849806 @default.
• W1995993143 hasConceptScore W1995993143C2779959927 @default.
• W1995993143 hasConceptScore W1995993143C2911091166 @default.
• W1995993143 hasConceptScore W1995993143C4224716 @default.
• W1995993143 hasConceptScore W1995993143C71924100 @default.
• W1995993143 hasIssue "5" @default.
• W1995993143 hasLocation W19959931431 @default.
• W1995993143 hasLocation W19959931432 @default.
• W1995993143 hasOpenAccess W1995993143 @default.
• W1995993143 hasPrimaryLocation W19959931431 @default.
• W1995993143 hasRelatedWork W131145346 @default.
• W1995993143 hasRelatedWork W2001495175 @default.
• W1995993143 hasRelatedWork W2056777658 @default.
• W1995993143 hasRelatedWork W2057390952 @default.
• W1995993143 hasRelatedWork W2795155943 @default.
• W1995993143 hasRelatedWork W2924722371 @default.
• W1995993143 hasRelatedWork W3144672929 @default.
• W1995993143 hasRelatedWork W4210664167 @default.
• W1995993143 hasRelatedWork W4232041577 @default.
• W1995993143 hasRelatedWork W4249287024 @default.
• W1995993143 hasVolume "134" @default.
• W1995993143 isParatext "false" @default.
• W1995993143 isRetracted "false" @default.
• W1995993143 magId "1995993143" @default.
• W1995993143 workType "article" @default.