FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996002665> ?p ?o ?g. }

• W1996002665 endingPage "75" @default.
• W1996002665 startingPage "68" @default.
• W1996002665 abstract "Summary The human lectin galectin‐3 is a multifunctional effector with special functions in regulation of adhesion and apoptosis. Its unique trimodular organization includes the 12‐residue N‐terminal sequence, a substrate for protein kinase CK1‐dependent phosphorylation. As a step towards elucidating its significance, we prepared phosphorylated galectin‐3, labelled it and used it as a tool in histochemistry. We monitored normal and malignant squamous epithelia. Binding was suprabasal with obvious positive correlation to the degree of differentiation and negative correlation to proliferation. The staining pattern resembled that obtained with the unmodified lectin. Basal cell carcinomas were invariably negative. The epidermal positivity profile was akin to distribution of the desmosomal protein desmoglein, as also seen with keratinocytes in vitro . In all cases, binding was inhibitable by the presence of lactose, prompting further investigation of the activity of the lectin site by a sensitive biochemical method, i.e. isothermal titration calorimetry. The overall affinity and the individual enthalpic and entropic contributions were determined. No effect of phosphorylation was revealed. This strategic combination of histo‐ and biochemical techniques applied to an endogenous effector after its processing by a protein kinase thus enabled a detailed monitoring of the binding properties of the post‐translationally modified lectin. It underscores the value of using endogenous lectins as a histochemical tool. The documented approach has merit for applications beyond lectinology." @default.
• W1996002665 created "2016-06-24" @default.
• W1996002665 creator A5015988586 @default.
• W1996002665 creator A5037250841 @default.
• W1996002665 creator A5039138618 @default.
• W1996002665 creator A5057537307 @default.
• W1996002665 creator A5061586215 @default.
• W1996002665 creator A5071296330 @default.
• W1996002665 creator A5078497380 @default.
• W1996002665 date "2009-01-14" @default.
• W1996002665 modified "2023-10-18" @default.
• W1996002665 title "Phosphorylated Human Lectin Galectin-3: Analysis of Ligand Binding by Histochemical Monitoring of Normal/Malignant Squamous Epithelia and by Isothermal Titration Calorimetry" @default.
• W1996002665 cites W117529435 @default.
• W1996002665 cites W1487549050 @default.
• W1996002665 cites W1497849810 @default.
• W1996002665 cites W1498601328 @default.
• W1996002665 cites W1585578818 @default.
• W1996002665 cites W1963590611 @default.
• W1996002665 cites W1964404766 @default.
• W1996002665 cites W1964992965 @default.
• W1996002665 cites W1974252366 @default.
• W1996002665 cites W1978057604 @default.
• W1996002665 cites W1979128075 @default.
• W1996002665 cites W1980045097 @default.
• W1996002665 cites W1980993209 @default.
• W1996002665 cites W1985666458 @default.
• W1996002665 cites W1990489811 @default.
• W1996002665 cites W1995842466 @default.
• W1996002665 cites W1998493826 @default.
• W1996002665 cites W2000887346 @default.
• W1996002665 cites W2002355793 @default.
• W1996002665 cites W2003195969 @default.
• W1996002665 cites W2010715276 @default.
• W1996002665 cites W2025653570 @default.
• W1996002665 cites W2027999658 @default.
• W1996002665 cites W2036938579 @default.
• W1996002665 cites W2041518177 @default.
• W1996002665 cites W2051053703 @default.
• W1996002665 cites W2052232627 @default.
• W1996002665 cites W2057134325 @default.
• W1996002665 cites W2059984219 @default.
• W1996002665 cites W2064431406 @default.
• W1996002665 cites W2065037826 @default.
• W1996002665 cites W2074082344 @default.
• W1996002665 cites W2078391564 @default.
• W1996002665 cites W2082421146 @default.
• W1996002665 cites W2084744176 @default.
• W1996002665 cites W2088724065 @default.
• W1996002665 cites W2090435716 @default.
• W1996002665 cites W2104241705 @default.
• W1996002665 cites W2104784998 @default.
• W1996002665 cites W2110964386 @default.
• W1996002665 cites W2113975517 @default.
• W1996002665 cites W2122263758 @default.
• W1996002665 cites W2130947821 @default.
• W1996002665 cites W2135308770 @default.
• W1996002665 cites W2141144220 @default.
• W1996002665 cites W2144088373 @default.
• W1996002665 cites W2144562803 @default.
• W1996002665 cites W2151227852 @default.
• W1996002665 cites W2157903759 @default.
• W1996002665 cites W2159692314 @default.
• W1996002665 cites W2317651936 @default.
• W1996002665 cites W2461191590 @default.
• W1996002665 cites W347531457 @default.
• W1996002665 cites W4245953818 @default.
• W1996002665 cites W4312552603 @default.
• W1996002665 doi "https://doi.org/10.1111/j.1439-0264.2008.00899.x" @default.
• W1996002665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18983621" @default.
• W1996002665 hasPublicationYear "2009" @default.
• W1996002665 type Work @default.
• W1996002665 sameAs 1996002665 @default.
• W1996002665 citedByCount "25" @default.
• W1996002665 countsByYear W19960026652012 @default.
• W1996002665 countsByYear W19960026652013 @default.
• W1996002665 countsByYear W19960026652014 @default.
• W1996002665 countsByYear W19960026652019 @default.
• W1996002665 crossrefType "journal-article" @default.
• W1996002665 hasAuthorship W1996002665A5015988586 @default.
• W1996002665 hasAuthorship W1996002665A5037250841 @default.
• W1996002665 hasAuthorship W1996002665A5039138618 @default.
• W1996002665 hasAuthorship W1996002665A5057537307 @default.
• W1996002665 hasAuthorship W1996002665A5061586215 @default.
• W1996002665 hasAuthorship W1996002665A5071296330 @default.
• W1996002665 hasAuthorship W1996002665A5078497380 @default.
• W1996002665 hasConcept C11960822 @default.
• W1996002665 hasConcept C153911025 @default.
• W1996002665 hasConcept C156911925 @default.
• W1996002665 hasConcept C185592680 @default.
• W1996002665 hasConcept C2780758401 @default.
• W1996002665 hasConcept C55493867 @default.
• W1996002665 hasConcept C86803240 @default.
• W1996002665 hasConcept C95444343 @default.
• W1996002665 hasConceptScore W1996002665C11960822 @default.
• W1996002665 hasConceptScore W1996002665C153911025 @default.
• W1996002665 hasConceptScore W1996002665C156911925 @default.
• W1996002665 hasConceptScore W1996002665C185592680 @default.
• W1996002665 hasConceptScore W1996002665C2780758401 @default.

• next