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- W1996005242 abstract "Human immunodeficiency virus (HIV)-1 infection causes progressive impairment of the immune system in humans, characterized by depletion of CD4 T cells and loss of T cell function. Increased markers of T cell activation and lymphoid hyperplasia suggest that chronic T cell activation persists in immunocompromised hosts, and contributes to the exhaustion of immune functions. Here we propose a revision of this hypothesis, in which we suggest that chronic activation of innate immunity may negatively affect adaptive T cell-mediated responses. We hypothesize that constant exposure of the effector cells of innate immunity to HIV results in their chronic hyperactivation, with deleterious effects on T cells. In particular, plasmacytoid dendritic cells (pDC) may be highly susceptible to HIV-induced activation due to its interaction with the cellular receptor CD4, expressed by pDC. Subsequent production of type I interferon and indoleamine 2,3-dioxygenase may exert suppressive and cytotoxic effects on T cells." @default.
- W1996005242 created "2016-06-24" @default.
- W1996005242 creator A5004374605 @default.
- W1996005242 creator A5064542288 @default.
- W1996005242 date "2008-03-01" @default.
- W1996005242 modified "2023-10-11" @default.
- W1996005242 title "Chronic innate immune activation as a cause of HIV-1 immunopathogenesis" @default.
- W1996005242 cites W1484183405 @default.
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- W1996005242 cites W1801247541 @default.
- W1996005242 cites W1968276891 @default.
- W1996005242 cites W1975077407 @default.
- W1996005242 cites W1975929837 @default.
- W1996005242 cites W1978337555 @default.
- W1996005242 cites W1978436252 @default.
- W1996005242 cites W1978741561 @default.
- W1996005242 cites W1978913285 @default.
- W1996005242 cites W1979463789 @default.
- W1996005242 cites W1983796858 @default.
- W1996005242 cites W1985723826 @default.
- W1996005242 cites W1988468641 @default.
- W1996005242 cites W1988848925 @default.
- W1996005242 cites W1988941798 @default.
- W1996005242 cites W1999028733 @default.
- W1996005242 cites W2001137507 @default.
- W1996005242 cites W2005311345 @default.
- W1996005242 cites W2007130609 @default.
- W1996005242 cites W2013510722 @default.
- W1996005242 cites W2014533284 @default.
- W1996005242 cites W2016976278 @default.
- W1996005242 cites W2016985979 @default.
- W1996005242 cites W2019582452 @default.
- W1996005242 cites W2021059521 @default.
- W1996005242 cites W2022581009 @default.
- W1996005242 cites W2025346994 @default.
- W1996005242 cites W2030605921 @default.
- W1996005242 cites W2032094987 @default.
- W1996005242 cites W2035852466 @default.
- W1996005242 cites W2037427174 @default.
- W1996005242 cites W2037920661 @default.
- W1996005242 cites W2041416134 @default.
- W1996005242 cites W2042760698 @default.
- W1996005242 cites W2045038546 @default.
- W1996005242 cites W2045167121 @default.
- W1996005242 cites W2045361762 @default.
- W1996005242 cites W2048508312 @default.
- W1996005242 cites W2065445562 @default.
- W1996005242 cites W2067695164 @default.
- W1996005242 cites W2068891952 @default.
- W1996005242 cites W2072056970 @default.
- W1996005242 cites W2075081228 @default.
- W1996005242 cites W2081392083 @default.
- W1996005242 cites W2092980326 @default.
- W1996005242 cites W2097135837 @default.
- W1996005242 cites W2097707535 @default.
- W1996005242 cites W2100773847 @default.
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- W1996005242 cites W2117159361 @default.
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- W1996005242 cites W2122285073 @default.
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- W1996005242 cites W2125742253 @default.
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- W1996005242 cites W2137734211 @default.
- W1996005242 cites W2138901765 @default.
- W1996005242 cites W2141946661 @default.
- W1996005242 cites W2146934919 @default.
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- W1996005242 doi "https://doi.org/10.1016/j.clim.2007.08.015" @default.
- W1996005242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2275778" @default.
- W1996005242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17916442" @default.
- W1996005242 hasPublicationYear "2008" @default.
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