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• W1996012034 abstract "<i>Background/Aim:</i> The identification of the <i>vacA </i>intermediate region has provided new insights into the role of <i>vacA</i> heterogeneity in relation to gastro-duodenal pathogenesis. The aim of this study was to assess <i>vacA</i> polymorphism in Iranian <i>Helicobacter pylori </i>strains and its association with <i>cagA</i> as a major virulence determinant, gastric histopathology and disease. <i>Methods:</i><i>vacA</i> polymorphism and serum antibody responses were studied in 207 <i>H. pylori</i>-infected (139 NUD, 34 PUD, and 34 GC) patients and correlated with gastric histopathology. <i>Results:</i> Multivariate logistic regression analysis found intermediate region typing superior to signal or mid region typing for screening high risk patients. <i>vacA</i> i1 allele was identified as an independent predictor of dysplasia (OR = 9.044; 95% CI: 1.11–73.33). Possession of s1/i1/<i>cagA</i>⁺ strains was also identified as a predictor of intestinal metaplasia (OR = 3; 95% CI: 1.13–7.95), dysplasia (OR = 9.9; 95% CI: 1.23–80.86) and risk of GC (OR = 6.9; 95% CI: 2.5–18.66) as well as induction of anti-VacA sero-positivity (OR = 5.04; 95% CI: 1.8–13.6). Anti-VacA serology correctly detected 83.8% of s1/i1/<i>cagA</i>⁺ strains carried by high-risk patients. <i>Conclusions:</i> The current study emphasizes the implication of <i>vacA</i> polymorphic structure, especially the s1/i1/<i>cagA</i>⁺ genotype, in increasing the risk of GC by revealing their association with gastric pre-neoplastic changes and their reflection in VacA sero-positivity which encourages the application of noninvasive procedures in population screening." @default.
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• W1996012034 date "2009-01-01" @default.
• W1996012034 modified "2023-10-18" @default.
• W1996012034 title "Multiple Gene Status in <i>Helicobacter pylori</i> Strains and Risk of Gastric Cancer Development" @default.
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• W1996012034 doi "https://doi.org/10.1159/000229774" @default.
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