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- W1996014910 abstract "A practical second-generation synthesis of an advanced intermediate in our total synthesis of altohyrtin C (spongistatin 2) has been developed. A new approach to the C1-C15 (AB) portion features a vinyllithium addition to an aldehyde followed by a palladium-catalyzed allylic reduction to install the troublesome C13-C15 segment. Our general approach to the C16-C28 (CD) spiroketal has been retained, but some improvements have been made. Most notably, the kinetically controlled CD-spiroketalization reaction now proceeds in high yield with excellent diastereoselection. This new strategy uses the anti-aldol coupling used in our first-generation synthesis to join AB and CD fragments. A total of 9.6 g of intermediate 57 has been produced using this improved route." @default.
- W1996014910 created "2016-06-24" @default.
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- W1996014910 date "2003-09-27" @default.
- W1996014910 modified "2023-09-27" @default.
- W1996014910 title "A Second-Generation Synthesis of the C1−C28 Portion of the Altohyrtins (Spongistatins)" @default.
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- W1996014910 doi "https://doi.org/10.1021/ja030316h" @default.
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