FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996027334> ?p ?o ?g. }

• W1996027334 endingPage "1427" @default.
• W1996027334 startingPage "1418" @default.
• W1996027334 abstract "Bile acids have been suggested to be involved in biliary carcinogenesis, although the underlying mechanisms are yet to be established. The aim of this study was to investigate the carcinogenic effect of bile acids in the biliary tract in relation to oxidative stress. Immortalized mouse cholangiocytes were incubated with various bile acids, followed by measurement of reactive oxygen species (ROS) and the glutathione (GSH) level. As a marker of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG) expression in cholangiocytes was analyzed by flow cytometry. Then the expression of oxidative DNA repair enzymes in cholangiocytes was examined by real-time PCR. In addition, the long-term effect of bile acid-induced oxidative DNA damage on cholangiocytes was investigated using a mouse oligo DNA microarray. It was found that glycochenodeoxycholate (GCDC) induced the generation of ROS and the depletion of GSH. In contrast, no marked changes were induced by the other bile acids. The percentage of 8-OHdG-positive cells was also increased by GCDC, but the expression of oxidative DNA repair enzymes was not up-regulated. DNA microarray analysis showed marked changes of various genes associated with carcinogenesis (genes related to cell proliferation, angiogenesis, invasion, and metastasis). In conclusion, the long-term effect of oxidative DNA damage due to GCDC may promote carcinogenesis in the biliary tract. Furthermore, accumulation of 8-OHdG due to GCDC might contribute to the dysfunction of oxidative DNA repair enzymes." @default.
• W1996027334 created "2016-06-24" @default.
• W1996027334 creator A5016110387 @default.
• W1996027334 creator A5023958825 @default.
• W1996027334 creator A5039085019 @default.
• W1996027334 creator A5044686947 @default.
• W1996027334 creator A5067083998 @default.
• W1996027334 date "2005-12-01" @default.
• W1996027334 modified "2023-10-14" @default.
• W1996027334 title "Glycochenodeoxycholate plays a carcinogenic role in immortalized mouse cholangiocytes via oxidative DNA damage" @default.
• W1996027334 cites W116861903 @default.
• W1996027334 cites W1641337940 @default.
• W1996027334 cites W1909048318 @default.
• W1996027334 cites W1965121800 @default.
• W1996027334 cites W1967264163 @default.
• W1996027334 cites W1967601750 @default.
• W1996027334 cites W1981257252 @default.
• W1996027334 cites W1991975419 @default.
• W1996027334 cites W1996463505 @default.
• W1996027334 cites W2004463618 @default.
• W1996027334 cites W2006088607 @default.
• W1996027334 cites W2013503821 @default.
• W1996027334 cites W2026895762 @default.
• W1996027334 cites W2027658027 @default.
• W1996027334 cites W2039035641 @default.
• W1996027334 cites W2044199817 @default.
• W1996027334 cites W2065995561 @default.
• W1996027334 cites W2071864498 @default.
• W1996027334 cites W2081873467 @default.
• W1996027334 cites W2081991309 @default.
• W1996027334 cites W2082385840 @default.
• W1996027334 cites W2083994499 @default.
• W1996027334 cites W2089160559 @default.
• W1996027334 cites W2094503136 @default.
• W1996027334 cites W2095301528 @default.
• W1996027334 cites W2110722235 @default.
• W1996027334 cites W2112773853 @default.
• W1996027334 cites W2119631008 @default.
• W1996027334 cites W2125067226 @default.
• W1996027334 cites W2127689078 @default.
• W1996027334 cites W2132129574 @default.
• W1996027334 cites W2136966666 @default.
• W1996027334 cites W2145292722 @default.
• W1996027334 cites W2145349694 @default.
• W1996027334 cites W2155705356 @default.
• W1996027334 cites W2156716755 @default.
• W1996027334 cites W2156838592 @default.
• W1996027334 cites W2162404262 @default.
• W1996027334 cites W2164613158 @default.
• W1996027334 cites W2166277258 @default.
• W1996027334 cites W2419112036 @default.
• W1996027334 doi "https://doi.org/10.1016/j.freeradbiomed.2005.07.005" @default.
• W1996027334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16274877" @default.
• W1996027334 hasPublicationYear "2005" @default.
• W1996027334 type Work @default.
• W1996027334 sameAs 1996027334 @default.
• W1996027334 citedByCount "48" @default.
• W1996027334 countsByYear W19960273342012 @default.
• W1996027334 countsByYear W19960273342013 @default.
• W1996027334 countsByYear W19960273342014 @default.
• W1996027334 countsByYear W19960273342015 @default.
• W1996027334 countsByYear W19960273342016 @default.
• W1996027334 countsByYear W19960273342017 @default.
• W1996027334 countsByYear W19960273342018 @default.
• W1996027334 countsByYear W19960273342019 @default.
• W1996027334 countsByYear W19960273342020 @default.
• W1996027334 countsByYear W19960273342021 @default.
• W1996027334 countsByYear W19960273342022 @default.
• W1996027334 countsByYear W19960273342023 @default.
• W1996027334 crossrefType "journal-article" @default.
• W1996027334 hasAuthorship W1996027334A5016110387 @default.
• W1996027334 hasAuthorship W1996027334A5023958825 @default.
• W1996027334 hasAuthorship W1996027334A5039085019 @default.
• W1996027334 hasAuthorship W1996027334A5044686947 @default.
• W1996027334 hasAuthorship W1996027334A5067083998 @default.
• W1996027334 hasConcept C104317684 @default.
• W1996027334 hasConcept C114246631 @default.
• W1996027334 hasConcept C134935766 @default.
• W1996027334 hasConcept C143425029 @default.
• W1996027334 hasConcept C153911025 @default.
• W1996027334 hasConcept C181199279 @default.
• W1996027334 hasConcept C185592680 @default.
• W1996027334 hasConcept C2776151105 @default.
• W1996027334 hasConcept C48349386 @default.
• W1996027334 hasConcept C538909803 @default.
• W1996027334 hasConcept C552990157 @default.
• W1996027334 hasConcept C55493867 @default.
• W1996027334 hasConcept C555283112 @default.
• W1996027334 hasConcept C57600042 @default.
• W1996027334 hasConcept C86803240 @default.
• W1996027334 hasConceptScore W1996027334C104317684 @default.
• W1996027334 hasConceptScore W1996027334C114246631 @default.
• W1996027334 hasConceptScore W1996027334C134935766 @default.
• W1996027334 hasConceptScore W1996027334C143425029 @default.
• W1996027334 hasConceptScore W1996027334C153911025 @default.
• W1996027334 hasConceptScore W1996027334C181199279 @default.
• W1996027334 hasConceptScore W1996027334C185592680 @default.
• W1996027334 hasConceptScore W1996027334C2776151105 @default.

• next