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- W1996056285 abstract "See article by Baartscheer et al. [1] (pages 83–92) in this issue .Heart failure is one of the major causes of mortality and morbidity in the western world. Enormous investments have been made for researching the treatment of this disease with the aim of reconstructing the chain of events at the organ, cellular, and molecular levels that leads to cardiac hypertrophy and/or heart failure. This challenge is extremely complex because almost every cellular and molecular system is affected in heart failure. These modifications can be a cause or a consequence of heart failure, can be compensatory or detrimental, or can be simply epiphenomena.The ideal target for heart failure research is the identification of key factors that are commonly activated by the underlying diseases and are responsible for inducing the functional changes. Normalisation of these key factors would restore cardiac function or, at the very least, prevent further dysfunction. There is now evidence that one of these key factors is the Na+/H+-exchanger (NHE-1).Several studies have now shown that inhibiting the NHE-1 in heart failure is beneficial. In the present issue of Cardiovascular Research the article by Baartscheer et al. [1] presents further evidence for this effect.Investigations into the role of the NHE-1 in cardiac disease have been examined under two main clinical scenarios: (1) in the setting of ischaemia/reperfusion; (2) during progression from hypertrophy to heart failure. … *Corresponding author. Tel.: +44 1895 453 874; fax: +44 1895 828 900. Email address: c.terracciano{at}imperial.ac.uk" @default.
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- W1996056285 date "2005-01-01" @default.
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- W1996056285 title "Less Na/H-exchanger to treat heart failure: a simple solution for a complex problem?" @default.
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- W1996056285 doi "https://doi.org/10.1016/j.cardiores.2004.10.028" @default.
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