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- W1996063886 abstract "Twenty-one patients with severe hypertension, refractory to treatment with diuretics, beta-adrenoreceptor blocking drugs, and hydralazine, were treated with minoxidil replacing hydralazine as the vasodilating component in triple-drug therapy. With minoxidil (average dose, 22 mg/day), blood pressure decreased from 208/118/ to 164/92 mm Hg without the appearance of orthostatic hypotension. There was no increase in pulse in pulse rate. Only 1 patient had to discontinue the minoxidil treatment because of severe headache, and I patient died during follow-up for 6–38 months. The glomerular filtration rate ([***Cr]EDTA clearance) was determined in 12 patients before and during long-term minoxidil therapy. No signification reduction was observed in 10 patients with primary hypertension, while 2 patients with chronic glomerulonephritis showed a slow reduction of filtration rate. Peripheral hemodynamic experiments on the calf muscle blood flow were made with venous occlusion plethysmography at rest and during hyperemia after arterial occlusion and superimposed muscle work. Systemic blood pressures ws recorded simultaneously with the flow determinations, and the vascular resistance at rest and during complete vasodilatation was calculated from the mean arterial pressure blood flow ratio. After the change to minoxidil a considerable increase in resting blood flow to the calf muscle was noted. This increase was associated with a significant decrease in calculated vascular resistance and was unaltered during 3 years of follow-up. No change was found in the resistance at maximal dilation, considered to reflect the average radius of the resistance vessels of the muscle tissue. Consequently, no sign of reversibility of the vascular abnormality was demonstrated after 3 years of good blood pressure control in patients previously refractory to antihypertensive treatment." @default.
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- W1996063886 date "1980-01-01" @default.
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- W1996063886 title "Renal Function and Vascular Resistance During Long-Term Minoxidil Treatment of Severe Hypertension" @default.
- W1996063886 doi "https://doi.org/10.1097/00005344-198000022-00005" @default.
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