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- W1996067562 abstract "We showed that expression of MRJ (DNAJB6) protein is lost in invasive ductal carcinoma, and restoration of MRJ(L) restricts malignant behavior of breast cancer and melanoma cells. However, the signaling pathways influenced by MRJ(L) are largely unknown. Our observations revealed that MRJ(L) expression causes changes in cell morphology concomitant with down-regulation of several mesenchymal markers, viz. vimentin, N-cadherin, Twist, and Slug, and up-regulation of epithelial marker keratin 18. Importantly, MRJ(L) expression led to reduced levels of beta-catenin, an epithelial mesenchymal transition marker, and a critical player in the Wnt pathway. We found that MRJ(L) up-regulates expression of DKK1, a well known Wnt/beta-catenin signaling inhibitor, that causes degradation of beta-catenin. Re-expression of DNAJB6 alters the Wnt/beta-catenin signaling in cancer cells, leading to partial reversal of the mesenchymal phenotype. Thus, MRJ(L) may play a role in maintaining an epithelial phenotype, and inhibition of the Wnt/beta-catenin pathway may be one of the potential mechanisms contributing to the restriction of malignant behavior by MRJ(L)." @default.
- W1996067562 created "2016-06-24" @default.
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- W1996067562 creator A5017356428 @default.
- W1996067562 creator A5031550114 @default.
- W1996067562 creator A5052594464 @default.
- W1996067562 date "2010-08-01" @default.
- W1996067562 modified "2023-10-18" @default.
- W1996067562 title "DNAJB6 Induces Degradation of β-Catenin and Causes Partial Reversal of Mesenchymal Phenotype" @default.
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- W1996067562 doi "https://doi.org/10.1074/jbc.m109.094847" @default.
- W1996067562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2915705" @default.
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- W1996067562 hasPublicationYear "2010" @default.
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