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- W1996069021 abstract "Significance We functionally profiled cells from a locus of the mouse brainstem that contains the neuronal network responsible for generating breathing patterns. By uncovering cell-specific constellations (i.e., distinctive combinations of receptors and ion channels that define each cell type), we identified specific neuronal classes and subclasses within the network. We discovered neuromodulators affecting the activity of specific neuronal subclasses within the functional network. This study provides proof-of-principle that a pharmacological strategy for altering the activity of a specific type of neuron can be developed which has potential as a parallel or complementary approach to genetic strategies for functionally perturbing a specific neuronal cell type in vivo. Additionally, unlike genetic approaches, this pharmacological approach is directly applicable to nonmodel organisms." @default.
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- W1996069021 date "2014-04-14" @default.
- W1996069021 modified "2023-10-09" @default.
- W1996069021 title "Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling" @default.
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- W1996069021 doi "https://doi.org/10.1073/pnas.1404421111" @default.
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