FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996069345> ?p ?o ?g. }

• W1996069345 abstract "Non-alcoholic fatty liver disease represents a set of liver lesions similar to those induced by alcohol that develop in individuals with no alcohol abuse. When lesions consist of fatty and hydropic degeneration, inflammation, and eventually fibrosis, the condition is designated non-alcoholic steatohepatitis (NASH). The pathogenesis of these lesions is not clearly understood, but they are associated with insulin resistance in most cases. As a result, abdominal fat tissue lipolysis and excessive fatty acid uptake by the liver occur. This, together with a disturbance of triglyceride export as VLDL, results in fatty liver development. Both the inflammatory and hepatocellular degenerative components of NASH are attributed to oxidative stress. Mitochondrial respiratory chain loss of activity plays a critical role in the genesis of latter stress. This may be initiated by an increase in the hepatic TNFalpha, iNOS induction, peroxynitrite formation, tyrosine nitration and inactivation of enzymes making up this chain. Consequences of oxidative stress include: lipid peroxidation in cell membranes, stellate cell activation in the liver, liver fibrosis, chronic inflammation, and apoptosis." @default.
• W1996069345 created "2016-06-24" @default.
• W1996069345 creator A5060789702 @default.
• W1996069345 creator A5063029087 @default.
• W1996069345 creator A5063117858 @default.
• W1996069345 creator A5079221068 @default.
• W1996069345 date "2006-11-01" @default.
• W1996069345 modified "2023-10-12" @default.
• W1996069345 title "Non-alcoholic fatty liver disease: From insulin resistance to mitochondrial dysfunction" @default.
• W1996069345 cites W1493065360 @default.
• W1996069345 cites W1500094754 @default.
• W1996069345 cites W1501176525 @default.
• W1996069345 cites W1507526272 @default.
• W1996069345 cites W1524987786 @default.
• W1996069345 cites W1527863790 @default.
• W1996069345 cites W1532146312 @default.
• W1996069345 cites W1534360145 @default.
• W1996069345 cites W1538061282 @default.
• W1996069345 cites W1538404459 @default.
• W1996069345 cites W1541439044 @default.
• W1996069345 cites W15618468 @default.
• W1996069345 cites W1562891630 @default.
• W1996069345 cites W1583419793 @default.
• W1996069345 cites W1585600011 @default.
• W1996069345 cites W1587875569 @default.
• W1996069345 cites W1690535660 @default.
• W1996069345 cites W169476524 @default.
• W1996069345 cites W174752440 @default.
• W1996069345 cites W1762131358 @default.
• W1996069345 cites W1784102749 @default.
• W1996069345 cites W1945253873 @default.
• W1996069345 cites W1945313674 @default.
• W1996069345 cites W1963594193 @default.
• W1996069345 cites W1965019476 @default.
• W1996069345 cites W1966607943 @default.
• W1996069345 cites W1967251260 @default.
• W1996069345 cites W1967894078 @default.
• W1996069345 cites W1968580611 @default.
• W1996069345 cites W1969941249 @default.
• W1996069345 cites W1970468997 @default.
• W1996069345 cites W1970781279 @default.
• W1996069345 cites W1971465028 @default.
• W1996069345 cites W1971839518 @default.
• W1996069345 cites W1972326983 @default.
• W1996069345 cites W1972590376 @default.
• W1996069345 cites W1973382595 @default.
• W1996069345 cites W1973573989 @default.
• W1996069345 cites W1973842058 @default.
• W1996069345 cites W1974033843 @default.
• W1996069345 cites W1974436444 @default.
• W1996069345 cites W1974437991 @default.
• W1996069345 cites W1974569401 @default.
• W1996069345 cites W1976829005 @default.
• W1996069345 cites W1977188464 @default.
• W1996069345 cites W1977565165 @default.
• W1996069345 cites W1979590516 @default.
• W1996069345 cites W1979867623 @default.
• W1996069345 cites W1980223046 @default.
• W1996069345 cites W1982235892 @default.
• W1996069345 cites W1982578021 @default.
• W1996069345 cites W1982584622 @default.
• W1996069345 cites W1983417944 @default.
• W1996069345 cites W1984077928 @default.
• W1996069345 cites W1984513597 @default.
• W1996069345 cites W1985592156 @default.
• W1996069345 cites W1986665522 @default.
• W1996069345 cites W1988208946 @default.
• W1996069345 cites W1988269137 @default.
• W1996069345 cites W1988870963 @default.
• W1996069345 cites W1988981256 @default.
• W1996069345 cites W1989616639 @default.
• W1996069345 cites W1989639366 @default.
• W1996069345 cites W1990034749 @default.
• W1996069345 cites W1990051101 @default.
• W1996069345 cites W1990699073 @default.
• W1996069345 cites W1991401793 @default.
• W1996069345 cites W1992566551 @default.
• W1996069345 cites W1993203791 @default.
• W1996069345 cites W1994800074 @default.
• W1996069345 cites W1994952536 @default.
• W1996069345 cites W1995000970 @default.
• W1996069345 cites W1996379134 @default.
• W1996069345 cites W1996446469 @default.
• W1996069345 cites W1996713062 @default.
• W1996069345 cites W1997402768 @default.
• W1996069345 cites W1998002161 @default.
• W1996069345 cites W1999098395 @default.
• W1996069345 cites W2002008036 @default.
• W1996069345 cites W2002350157 @default.
• W1996069345 cites W2003385540 @default.
• W1996069345 cites W2003471941 @default.
• W1996069345 cites W2004267786 @default.
• W1996069345 cites W2006023528 @default.
• W1996069345 cites W2006304210 @default.
• W1996069345 cites W2006668347 @default.
• W1996069345 cites W2007194743 @default.
• W1996069345 cites W2008515523 @default.
• W1996069345 cites W2008732319 @default.
• W1996069345 cites W2008869160 @default.
• W1996069345 cites W2008976169 @default.

• next