FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996083965> ?p ?o ?g. }

• W1996083965 endingPage "34" @default.
• W1996083965 startingPage "27" @default.
• W1996083965 abstract "Background: AIDS-related death and disease rates have declined in the highly active antiretroviral therapy (HAART) era and remain low; however, current causes of death in HAART-treated patients remain ill defined. Objective: To describe mortality trends and causes of death among HIV-infected patients in the HAART era. Design: Prospective, multicenter, observational cohort study of participants in the HIV Outpatient Study who were treated from January 1996 through December 2004. Measurements: Rates of death, opportunistic disease, and other non-AIDS-defining illnesses (NADIs) determined to be primary or secondary causes of death. Results: Among 6945 HIV-infected patients followed for a median of 39.2 months, death rates fell from 7.0 deaths/100 person-years of observation in 1996 to 1.3 deaths/100 person-years in 2004 (P = 0.008 for trend). Deaths that included AIDS-related causes decreased from 3.79/100 person-years in 1996 to 0.32/100 person-years in 2004 (P = 0.008). Proportional increases in deaths involving liver disease, bacteremia/sepsis, gastrointestinal disease, non-AIDS malignancies, and renal disease also occurred (P = <0.001, 0.017, 0.006, <0.001, and 0.037, respectively.) Hepatic disease was the only reported cause of death for which absolute rates increased over time, albeit not significantly, from 0.09/100 person-years in 1996 to 0.16/100 person-years in 2004 (P = 0.10). The percentage of deaths due exclusively to NADI rose from 13.1% in 1996 to 42.5% in 2004 (P < 0.001 for trend), the most frequent of which were cardiovascular, hepatic, and pulmonary disease, and non-AIDS malignancies in 2004. Mean CD4 cell counts closest to death (n = 486 deaths) increased from 59 cells/μL in 1996 to 287 cells/μL in 2004 (P < 0.001 for trend). Patients dying of NADI causes were more HAART experienced and initiated HAART at higher CD4 cell counts than those who died with AIDS (34.5% vs 16.8%, respectively, received HAART for 4 of more years, P < 0.0001; 22.4% vs 7.8%, respectively, initiated HAART with CD4 cell counts of more than 350 cells/μL, P < 0.001). Conclusions: Although overall death rates remained low through 2004, the proportion of deaths attributable to non-AIDS diseases increased and prominently included hepatic, cardiovascular, and pulmonary diseases, as well as non-AIDS malignancies. Longer time spent receiving HAART and higher CD4 cell counts at HAART initiation were associated with death from non-AIDS causes. CD4 cell count at time of death increased over time." @default.
• W1996083965 created "2016-06-24" @default.
• W1996083965 creator A5020714737 @default.
• W1996083965 creator A5050177630 @default.
• W1996083965 creator A5070816894 @default.
• W1996083965 creator A5078945580 @default.
• W1996083965 creator A5084743292 @default.
• W1996083965 creator A5088885158 @default.
• W1996083965 creator A5089855984 @default.
• W1996083965 date "2006-09-01" @default.
• W1996083965 modified "2023-10-14" @default.
• W1996083965 title "Mortality in the Highly Active Antiretroviral Therapy Era" @default.
• W1996083965 cites W1983231859 @default.
• W1996083965 cites W1988199533 @default.
• W1996083965 cites W1993484328 @default.
• W1996083965 cites W1996434966 @default.
• W1996083965 cites W2005321051 @default.
• W1996083965 cites W2006341180 @default.
• W1996083965 cites W2011529667 @default.
• W1996083965 cites W2027863312 @default.
• W1996083965 cites W2043427266 @default.
• W1996083965 cites W2060825301 @default.
• W1996083965 cites W2063244503 @default.
• W1996083965 cites W2072177352 @default.
• W1996083965 cites W2074260600 @default.
• W1996083965 cites W2078452445 @default.
• W1996083965 cites W2084319458 @default.
• W1996083965 cites W2092195709 @default.
• W1996083965 cites W2099509337 @default.
• W1996083965 cites W2110400973 @default.
• W1996083965 cites W2128483742 @default.
• W1996083965 cites W2140123670 @default.
• W1996083965 cites W2146329405 @default.
• W1996083965 cites W2168418305 @default.
• W1996083965 cites W2169085525 @default.
• W1996083965 cites W2318289184 @default.
• W1996083965 cites W2324473093 @default.
• W1996083965 cites W2327498456 @default.
• W1996083965 cites W2330811833 @default.
• W1996083965 doi "https://doi.org/10.1097/01.qai.0000233310.90484.16" @default.
• W1996083965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16878047" @default.
• W1996083965 hasPublicationYear "2006" @default.
• W1996083965 type Work @default.
• W1996083965 sameAs 1996083965 @default.
• W1996083965 citedByCount "1263" @default.
• W1996083965 countsByYear W19960839652012 @default.
• W1996083965 countsByYear W19960839652013 @default.
• W1996083965 countsByYear W19960839652014 @default.
• W1996083965 countsByYear W19960839652015 @default.
• W1996083965 countsByYear W19960839652016 @default.
• W1996083965 countsByYear W19960839652017 @default.
• W1996083965 countsByYear W19960839652018 @default.
• W1996083965 countsByYear W19960839652019 @default.
• W1996083965 countsByYear W19960839652020 @default.
• W1996083965 countsByYear W19960839652021 @default.
• W1996083965 countsByYear W19960839652022 @default.
• W1996083965 countsByYear W19960839652023 @default.
• W1996083965 crossrefType "journal-article" @default.
• W1996083965 hasAuthorship W1996083965A5020714737 @default.
• W1996083965 hasAuthorship W1996083965A5050177630 @default.
• W1996083965 hasAuthorship W1996083965A5070816894 @default.
• W1996083965 hasAuthorship W1996083965A5078945580 @default.
• W1996083965 hasAuthorship W1996083965A5084743292 @default.
• W1996083965 hasAuthorship W1996083965A5088885158 @default.
• W1996083965 hasAuthorship W1996083965A5089855984 @default.
• W1996083965 hasBestOaLocation W19960839651 @default.
• W1996083965 hasConcept C126322002 @default.
• W1996083965 hasConcept C179755657 @default.
• W1996083965 hasConcept C187212893 @default.
• W1996083965 hasConcept C188816634 @default.
• W1996083965 hasConcept C201903717 @default.
• W1996083965 hasConcept C2778384902 @default.
• W1996083965 hasConcept C2779134260 @default.
• W1996083965 hasConcept C2779443120 @default.
• W1996083965 hasConcept C29374701 @default.
• W1996083965 hasConcept C501593827 @default.
• W1996083965 hasConcept C71924100 @default.
• W1996083965 hasConcept C72563966 @default.
• W1996083965 hasConcept C86803240 @default.
• W1996083965 hasConcept C89423630 @default.
• W1996083965 hasConceptScore W1996083965C126322002 @default.
• W1996083965 hasConceptScore W1996083965C179755657 @default.
• W1996083965 hasConceptScore W1996083965C187212893 @default.
• W1996083965 hasConceptScore W1996083965C188816634 @default.
• W1996083965 hasConceptScore W1996083965C201903717 @default.
• W1996083965 hasConceptScore W1996083965C2778384902 @default.
• W1996083965 hasConceptScore W1996083965C2779134260 @default.
• W1996083965 hasConceptScore W1996083965C2779443120 @default.
• W1996083965 hasConceptScore W1996083965C29374701 @default.
• W1996083965 hasConceptScore W1996083965C501593827 @default.
• W1996083965 hasConceptScore W1996083965C71924100 @default.
• W1996083965 hasConceptScore W1996083965C72563966 @default.
• W1996083965 hasConceptScore W1996083965C86803240 @default.
• W1996083965 hasConceptScore W1996083965C89423630 @default.
• W1996083965 hasIssue "1" @default.
• W1996083965 hasLocation W19960839651 @default.
• W1996083965 hasLocation W19960839652 @default.
• W1996083965 hasLocation W19960839653 @default.

• next