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- W1996085747 abstract "Etoposide/cisplatin is the standard chemotherapy regimen used in the United States for the treatment of smallcell lung cancer (SCLC). A wide variety of dose and schedules have been employed when managing these patients. We conducted an analysis of the phase II/III trials of etoposide/cisplatin in the past 20 years to determine whether the dose and cycle of either drug affected outcomes in patients with extensive SCLC. We identified 15 phase I/II studies, which included 1419 patients. Etoposide doses per cycle ranged from 180 mg/m2 to 510 mg/m2 and cisplatin doses per cycle ranged from 80 mg/m2 to 280 mg/m2. With logistic regression analysis, we found that increasing doses of etoposide resulted in increased complete response rates (P = 0.01) but had no impact on overall response rates. Cisplatin dose per cycle had no influence on complete or overall response. With linear regression analysis, we were unable to find a relationship between survival and dose per cycle of etoposide or cisplatin. Variations in the administration of this regimen had no impact on outcomes in patients with extensive SCLC." @default.
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- W1996085747 date "2004-03-01" @default.
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- W1996085747 title "The Impact of Dose per Cycle of Etoposide and Cisplatin on Outcomes in Patients with Extensive Small-Cell Lung Cancer" @default.
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- W1996085747 doi "https://doi.org/10.3816/clc.2004.n.009" @default.
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