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• W1996096916 abstract "ABSTRACT An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles. However, the extent to which escape mutations affect other viral proteins during natural infection is not well understood. We generated recombinant viruses encoding plasma HIV-1 RNA integrase sequences from antiretroviral-naïve individuals with early ( n = 88) and chronic ( n = 304) infections and measured the in vitro RC of each. In contrast to data from previous studies of Gag, we observed little evidence that host HLA allele expression was associated with integrase RC. A modest negative correlation was observed between the number of HLA-B-associated integrase polymorphisms and RC in chronic infection ( R = −0.2; P = 0.003); however, this effect was not driven by mutations restricted by protective HLA alleles. Notably, the integrase variants S119R, G163E, and I220L, which represent uncommon polymorphisms associated with HLA-C*05, -A*33, and -B*52, respectively, correlated with lower RC (all q < 0.2). We identified a novel C*05-restricted epitope (HTDNGSNF 114–121 ) that likely contributes to the selection of the S119R variant, the polymorphism most significantly associated with lower RC in patient sequences. An NL4-3 mutant encoding the S119R polymorphism displayed a ∼35%-reduced function that was rescued by a single compensatory mutation of A91E. Together, these data indicate that substantial HLA-driven attenuation of integrase is not a general phenomenon during HIV-1 adaptation to host immunity. However, uncommon polymorphisms selected by HLA alleles that are not conventionally regarded to be protective may be associated with impaired protein function. Vulnerable epitopes in integrase might therefore be considered for future vaccine strategies." @default.
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• W1996096916 date "2012-06-15" @default.
• W1996096916 modified "2023-10-07" @default.
• W1996096916 title "Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity" @default.
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• W1996096916 cites W1967794036 @default.
• W1996096916 cites W1976608858 @default.
• W1996096916 cites W1997015701 @default.
• W1996096916 cites W1999510588 @default.
• W1996096916 cites W1999844225 @default.
• W1996096916 cites W2001789973 @default.
• W1996096916 cites W2014893636 @default.
• W1996096916 cites W2027504999 @default.
• W1996096916 cites W2043293085 @default.
• W1996096916 cites W2047489384 @default.
• W1996096916 cites W2051453551 @default.
• W1996096916 cites W2051518498 @default.
• W1996096916 cites W2053695022 @default.
• W1996096916 cites W2062055614 @default.
• W1996096916 cites W2078360449 @default.
• W1996096916 cites W2082523699 @default.
• W1996096916 cites W2085992210 @default.
• W1996096916 cites W2089850283 @default.
• W1996096916 cites W2092434970 @default.
• W1996096916 cites W2099272076 @default.
• W1996096916 cites W2103314023 @default.
• W1996096916 cites W2103546861 @default.
• W1996096916 cites W2105813980 @default.
• W1996096916 cites W2106095665 @default.
• W1996096916 cites W2107666854 @default.
• W1996096916 cites W2108446353 @default.
• W1996096916 cites W2108603500 @default.
• W1996096916 cites W2112507995 @default.
• W1996096916 cites W2113940664 @default.
• W1996096916 cites W2116067059 @default.
• W1996096916 cites W2116296845 @default.
• W1996096916 cites W2116745209 @default.
• W1996096916 cites W2118115182 @default.
• W1996096916 cites W2118836866 @default.
• W1996096916 cites W2120529419 @default.
• W1996096916 cites W2124842769 @default.
• W1996096916 cites W2125377484 @default.
• W1996096916 cites W2126018286 @default.
• W1996096916 cites W2126141460 @default.
• W1996096916 cites W2126862836 @default.
• W1996096916 cites W2127767954 @default.
• W1996096916 cites W2132262344 @default.
• W1996096916 cites W2135709828 @default.
• W1996096916 cites W2140333504 @default.
• W1996096916 cites W2141700353 @default.
• W1996096916 cites W2142831360 @default.
• W1996096916 cites W2142838880 @default.
• W1996096916 cites W2147134928 @default.
• W1996096916 cites W2148544227 @default.
• W1996096916 cites W2154595148 @default.
• W1996096916 cites W2155324027 @default.
• W1996096916 cites W2156383712 @default.
• W1996096916 cites W2158238436 @default.
• W1996096916 cites W2158783859 @default.
• W1996096916 cites W2158882181 @default.
• W1996096916 cites W2161020185 @default.
• W1996096916 cites W2161506007 @default.
• W1996096916 cites W2163977342 @default.
• W1996096916 cites W2164861987 @default.
• W1996096916 cites W2166236842 @default.
• W1996096916 cites W2169847792 @default.
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• W1996096916 doi "https://doi.org/10.1128/jvi.07133-11" @default.
• W1996096916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3393549" @default.
• W1996096916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22496233" @default.
• W1996096916 hasPublicationYear "2012" @default.

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