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- W1996097468 abstract "Abstract We have examined Na + ‐independent phenylalanine transport in Ehrlich cells having different degrees of membrane fatty acid saturation. These differences were produced by growing the cells in mice fed a fat‐free chow supplemented with either sunflower seed oil or coconut oil. Plasma membranes isolated from the cells grown on sunflower oil were enriched with polyenoic fatty acid, especially 18∶2, whereas those isolated from the cells grown on coconut oil were enriched in monoenoic fatty acids, primarily 16∶1 and 18∶1. Arrhenius plots of phenylalanine uptake showed two transitions. The temperatures of these transitions were different in the two cell preparations; 17 C and 24 C for the cells enriched in polyenoic fatty acids, 19 C and 28 C for those enriched in monoenoic fatty acids. Therefore, this transport system is sensitive to changes in the fatty acid composition of the lipid phase in which it operates. The activation energies, however, were the same in both cell preparations; 14, 8 and 4 kcal/mol. There also was no significant effect of the lipid modifications on either the K′ m or V′ max of this transport process. The K′ m for phenylalanine uptake from a choline medium remained constant as the temperature was raised from 17 C to 37 C, whereas the V′ max showed about a two‐fold increase in both cell types. Phenylalanine exodus from the cells into an amino acid‐free suspending medium, analyzed using first‐order kinetics, also was not influenced by these membrane fatty acid modifications. The changes in the transition temperatures probably reflect differences in the degree of fatty acid unsaturation of lipids that surround and interact with the phenylalanine carrier. Such differences, however, do not appreciably influence the catalytic activity of this transport system." @default.
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- W1996097468 title "Effects of membrane fatty acid composition on sodium-independent phenylalanine transport in Ehrlich cells" @default.
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- W1996097468 doi "https://doi.org/10.1007/bf02533437" @default.
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