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• W1996099327 abstract "The aim of this study was to investigate the cellular pathological responses of hepatopancreatic digestive cells from the periwinkle Littorina littorea exposed to the polycyclic aromatic hydrocarbon (PAH) fluoranthene and to ascertain whether any injurious effects were reversible within the experimental time scale. A secondary objective was to establish the relationship of the various reactions to animal health status, using lysosomal stability as an index of well-being. Exposure of snails to a concentration of 335 μg l−1 (1.7 μM) fluoranthene (seawater renewed and spiked daily with fluoranthene) for 5 days resulted in a reduction in lysosomal stability (neutral red retention) and endocytosis; and an increase in smooth endoplasmic reticulum (ER) and 7-ethoxycoumarin-o-deethylase (ECOD; measured as cyano-ECOD) activity measured in isolated live digestive cells. Exposed snails treated with clean seawater for a further 8 days resulted in a return to control levels of lysosomal stability, ECOD and ER; endocytosis showed only a partial recovery. Multi-variate and uni-variate analysis showed that there were strong correlations between the various cellular biomarker responses. These findings are interpretable within the current framework of molluscan biomarker responses to PAHs. Principal component analysis was used to derive the first principal component for endocytosis, ER and ECOD reactions and these were plotted against lysosomal stability as a measure of cellular well-being. The resulting significant regression represents the mapping of the individual biomarkers within health status space for a gradient of fluoranthene toxicity. From this analysis, we concluded that endocytosis is an indicator of healthy snails while proliferation of ER and to a lesser extent induced ECOD are indicative of dysfunction and reduced health. Finally, the results indicate that stress induced by chronic exposure to a PAH is reversible." @default.
• W1996099327 created "2016-06-24" @default.
• W1996099327 creator A5035962529 @default.
• W1996099327 creator A5044318214 @default.
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• W1996099327 date "2006-06-01" @default.
• W1996099327 modified "2023-09-24" @default.
• W1996099327 title "Pathological reactions and recovery of hepatopancreatic digestive cells from the marine snail Littorina littorea following exposure to a polycyclic aromatic hydrocarbon" @default.
• W1996099327 cites W10640494 @default.
• W1996099327 cites W1538904872 @default.
• W1996099327 cites W1966949685 @default.
• W1996099327 cites W1968006306 @default.
• W1996099327 cites W1970401090 @default.
• W1996099327 cites W1970578007 @default.
• W1996099327 cites W1971139179 @default.
• W1996099327 cites W1972253841 @default.
• W1996099327 cites W1973751291 @default.
• W1996099327 cites W1973966377 @default.
• W1996099327 cites W1978420385 @default.
• W1996099327 cites W1979117963 @default.
• W1996099327 cites W1980288642 @default.
• W1996099327 cites W1984112171 @default.
• W1996099327 cites W1984350117 @default.
• W1996099327 cites W1988268674 @default.
• W1996099327 cites W1990449494 @default.
• W1996099327 cites W1991251441 @default.
• W1996099327 cites W1994250392 @default.
• W1996099327 cites W1996227112 @default.
• W1996099327 cites W1996567488 @default.
• W1996099327 cites W2000484196 @default.
• W1996099327 cites W2001043627 @default.
• W1996099327 cites W2002195679 @default.
• W1996099327 cites W2003858064 @default.
• W1996099327 cites W2007320152 @default.
• W1996099327 cites W2008676944 @default.
• W1996099327 cites W2010789954 @default.
• W1996099327 cites W2011265703 @default.
• W1996099327 cites W2011622100 @default.
• W1996099327 cites W2014808107 @default.
• W1996099327 cites W2016097065 @default.
• W1996099327 cites W2016776629 @default.
• W1996099327 cites W2016984453 @default.
• W1996099327 cites W2020469902 @default.
• W1996099327 cites W2020567431 @default.
• W1996099327 cites W2025263397 @default.
• W1996099327 cites W2026811570 @default.
• W1996099327 cites W2026899709 @default.
• W1996099327 cites W2027126324 @default.
• W1996099327 cites W2027400330 @default.
• W1996099327 cites W2030445955 @default.
• W1996099327 cites W2038342056 @default.
• W1996099327 cites W2040675741 @default.
• W1996099327 cites W2046074328 @default.
• W1996099327 cites W2049492972 @default.
• W1996099327 cites W2050390330 @default.
• W1996099327 cites W2051091502 @default.
• W1996099327 cites W2054701044 @default.
• W1996099327 cites W2058816754 @default.
• W1996099327 cites W2061044463 @default.
• W1996099327 cites W2064180708 @default.
• W1996099327 cites W2067189361 @default.
• W1996099327 cites W2068927629 @default.
• W1996099327 cites W2069465339 @default.
• W1996099327 cites W2071436883 @default.
• W1996099327 cites W2076686872 @default.
• W1996099327 cites W2077083935 @default.
• W1996099327 cites W2080299971 @default.
• W1996099327 cites W2080630604 @default.
• W1996099327 cites W2086992292 @default.
• W1996099327 cites W2089773350 @default.
• W1996099327 cites W2089858841 @default.
• W1996099327 cites W2094999709 @default.
• W1996099327 cites W2108086395 @default.
• W1996099327 cites W2108104463 @default.
• W1996099327 cites W2129664378 @default.
• W1996099327 cites W2150999890 @default.
• W1996099327 cites W2151754882 @default.
• W1996099327 cites W2164237288 @default.
• W1996099327 cites W4232362205 @default.
• W1996099327 cites W88024062 @default.
• W1996099327 doi "https://doi.org/10.1016/j.marenvres.2006.01.001" @default.
• W1996099327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16516957" @default.
• W1996099327 hasPublicationYear "2006" @default.
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