Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996101068> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1996101068 endingPage "906" @default.
- W1996101068 startingPage "900" @default.
- W1996101068 abstract "Size and extent of a primary tumor strongly influences its response to irradiation. In order to investigate the relevance of this statement a randomized study was carried out in which irradiation of advanced carcinoma of head and neck was compared with a combined treatment where preirradiation intraarterial chemotherapy was administered in order to reduce the extent of the tumor. Intra-arterial chemotherapy (MTX 3–5 mg/day for 25–35 days) was given to 72 cases with lesions in the oral cavity, the oropharynx and maxillary antrum. Depending on response the patients were restaged and submitted to radiotherapy. In 68 other cases randomly allocated, radiotherapy only was given with the same modality and technique. After chemotherapy 21 cases with intraoral and 14 cases with maxillary antrum and oropharynx cancers were classified Stage I and II (0 and 23, respectively, before treatment). Results after 4 years follow up showed both local control and survival statistically better in the combined treatment in intraoral cancer where irradiation was delivered by a combination of external and interstitial technique. In the other cases no statistically significant difference was found. Amelioration of the results in the oral cavity could be ascribed to the greater use of interstitial irradiation due to the tumor shrinkage obtained with preirradiation chemotherapy more than to some synergistic effect between drug and irradiation. In 8 cases tumor cell kinetics were performed and the nuclear DNA content measured, but none of the kinetic parameters could be correlated with the response to treatment, even when the cancers were grouped according to their clinical growth characteristics. Late results in the irradiation of head and neck cancer probably depends on the presence of some resistant component which cannot be predicted by the cell kinetic or nuclear DNA content. Surgical excision or a second course of chemotherapy must be considered as a part of the multimodality treatment." @default.
- W1996101068 created "2016-06-24" @default.
- W1996101068 creator A5000236700 @default.
- W1996101068 creator A5015784925 @default.
- W1996101068 creator A5039931761 @default.
- W1996101068 creator A5046126735 @default.
- W1996101068 creator A5065431996 @default.
- W1996101068 creator A5076959334 @default.
- W1996101068 date "1978-03-01" @default.
- W1996101068 modified "2023-09-26" @default.
- W1996101068 title "The relevance of tumor size and cell kinetics as predictors of radiation response in head and neck cancer.A randomized study on the effect of intraarterial chemotherapy followed by radiotherapy" @default.
- W1996101068 cites W1996705393 @default.
- W1996101068 cites W2044484789 @default.
- W1996101068 cites W2046982645 @default.
- W1996101068 cites W2082424178 @default.
- W1996101068 cites W2148066167 @default.
- W1996101068 doi "https://doi.org/10.1002/1097-0142(197803)41:3<900::aid-cncr2820410317>3.0.co;2-i" @default.
- W1996101068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/346190" @default.
- W1996101068 hasPublicationYear "1978" @default.
- W1996101068 type Work @default.
- W1996101068 sameAs 1996101068 @default.
- W1996101068 citedByCount "40" @default.
- W1996101068 countsByYear W19961010682017 @default.
- W1996101068 countsByYear W19961010682018 @default.
- W1996101068 countsByYear W19961010682019 @default.
- W1996101068 countsByYear W19961010682021 @default.
- W1996101068 crossrefType "journal-article" @default.
- W1996101068 hasAuthorship W1996101068A5000236700 @default.
- W1996101068 hasAuthorship W1996101068A5015784925 @default.
- W1996101068 hasAuthorship W1996101068A5039931761 @default.
- W1996101068 hasAuthorship W1996101068A5046126735 @default.
- W1996101068 hasAuthorship W1996101068A5065431996 @default.
- W1996101068 hasAuthorship W1996101068A5076959334 @default.
- W1996101068 hasBestOaLocation W19961010681 @default.
- W1996101068 hasConcept C121608353 @default.
- W1996101068 hasConcept C126322002 @default.
- W1996101068 hasConcept C141071460 @default.
- W1996101068 hasConcept C2776530083 @default.
- W1996101068 hasConcept C2776694085 @default.
- W1996101068 hasConcept C2778496288 @default.
- W1996101068 hasConcept C2779013556 @default.
- W1996101068 hasConcept C2780283643 @default.
- W1996101068 hasConcept C2989005 @default.
- W1996101068 hasConcept C509974204 @default.
- W1996101068 hasConcept C71924100 @default.
- W1996101068 hasConceptScore W1996101068C121608353 @default.
- W1996101068 hasConceptScore W1996101068C126322002 @default.
- W1996101068 hasConceptScore W1996101068C141071460 @default.
- W1996101068 hasConceptScore W1996101068C2776530083 @default.
- W1996101068 hasConceptScore W1996101068C2776694085 @default.
- W1996101068 hasConceptScore W1996101068C2778496288 @default.
- W1996101068 hasConceptScore W1996101068C2779013556 @default.
- W1996101068 hasConceptScore W1996101068C2780283643 @default.
- W1996101068 hasConceptScore W1996101068C2989005 @default.
- W1996101068 hasConceptScore W1996101068C509974204 @default.
- W1996101068 hasConceptScore W1996101068C71924100 @default.
- W1996101068 hasIssue "3" @default.
- W1996101068 hasLocation W19961010681 @default.
- W1996101068 hasLocation W19961010682 @default.
- W1996101068 hasOpenAccess W1996101068 @default.
- W1996101068 hasPrimaryLocation W19961010681 @default.
- W1996101068 hasRelatedWork W1974239774 @default.
- W1996101068 hasRelatedWork W2147863910 @default.
- W1996101068 hasRelatedWork W2380931084 @default.
- W1996101068 hasRelatedWork W2389391102 @default.
- W1996101068 hasRelatedWork W2930119177 @default.
- W1996101068 hasRelatedWork W2994959075 @default.
- W1996101068 hasRelatedWork W2997863652 @default.
- W1996101068 hasRelatedWork W3018959328 @default.
- W1996101068 hasRelatedWork W3028617786 @default.
- W1996101068 hasRelatedWork W4245083039 @default.
- W1996101068 hasVolume "41" @default.
- W1996101068 isParatext "false" @default.
- W1996101068 isRetracted "false" @default.
- W1996101068 magId "1996101068" @default.
- W1996101068 workType "article" @default.