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- W1996104665 abstract "Measurement of testosterone production by the rat testis in vitro provides an extremely sensitive response system for the biological activities of luteinizing hormone (LH) and human chorionic gonadotrophin (HCG) activity in vitro. The sensitivity of the response to gonadotrophins depends upon the structural integrity of the isolated testis, as physical disruption by teasing apart the testis tubules results in substantial loss of the steroidogenic response to trophic hormones. The intact testis responds to as little as 0.2 ng HCG or 1 ng ovine LH, and shows maximal stimulation with 2 ng HCG or 10 ng ovine LH. Testosterone production in vitro was also markedly enhanced by Sepharose-coupled ovine LH and by dibutyryl cyclic AMP, consistent with the view that LH acts upon cell-membrane receptors to stimulate steroidogenesis in the testis via activation of adenyl cyclase. Desialylated gonadotrophins retained considerably greater biological activity in vitro than in vivo, indicating that the sialic acid residues are not essential for interaction of gonadotropins with their tissue receptor sites." @default.
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- W1996104665 date "1971-12-21" @default.
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- W1996104665 title "Gonadotrophin stimulation of testosterone production by the rat testis in vitro" @default.
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- W1996104665 doi "https://doi.org/10.1016/0304-4165(71)90161-9" @default.
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