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- W1996128058 abstract "IL-2 plays a critical role in the normal function of the immune system. A trophic factor for lymphocytes, IL-2 is required for mounting and sustaining adaptive T cell responses; however, IL-2 is also critical for immune regulation via its effects on regulatory T cells (Treg cells). Over the years, we have contributed to the understanding of the biology of IL-2 and its signaling through the IL-2 receptor and helped define the key role played by IL-2 in Treg development and function. Our data show that Treg cells have a heightened sensitivity to IL-2, which may create a therapeutic window to promote immune regulation by selective stimulation of Treg cells. We are now developing new efforts to translate this knowledge to the clinical arena, through our focused interest in Type 1 diabetes as a prototypic autoimmune disease. Specifically, we aim at developing IL-2-based therapeutic regimens and incorporate means to enhance antigen-specific Treg responses, for improved and more selective regulation of islet autoimmunity. In parallel, we are pursuing studies in preclinical models of autoimmunity and transplantation to define critical factors for successful adoptive Treg therapy and develop clinically applicable therapeutic protocols." @default.
- W1996128058 created "2016-06-24" @default.
- W1996128058 creator A5033971468 @default.
- W1996128058 creator A5065361211 @default.
- W1996128058 creator A5080375137 @default.
- W1996128058 date "2013-11-09" @default.
- W1996128058 modified "2023-09-27" @default.
- W1996128058 title "The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation" @default.
- W1996128058 cites W1502510454 @default.
- W1996128058 cites W1509117621 @default.
- W1996128058 cites W1518759830 @default.
- W1996128058 cites W1529004879 @default.
- W1996128058 cites W1537534922 @default.
- W1996128058 cites W1554901867 @default.
- W1996128058 cites W1555756643 @default.
- W1996128058 cites W1629285726 @default.
- W1996128058 cites W1652175895 @default.
- W1996128058 cites W1733558371 @default.
- W1996128058 cites W1797616819 @default.
- W1996128058 cites W1817869068 @default.
- W1996128058 cites W1878828051 @default.
- W1996128058 cites W1965327996 @default.
- W1996128058 cites W1973154630 @default.
- W1996128058 cites W1977020088 @default.
- W1996128058 cites W1977680996 @default.
- W1996128058 cites W1982051091 @default.
- W1996128058 cites W1985126564 @default.
- W1996128058 cites W1987128447 @default.
- W1996128058 cites W1992547979 @default.
- W1996128058 cites W1993142864 @default.
- W1996128058 cites W2000208875 @default.
- W1996128058 cites W2001311558 @default.
- W1996128058 cites W2002424665 @default.
- W1996128058 cites W2002726823 @default.
- W1996128058 cites W2005350058 @default.
- W1996128058 cites W2010505730 @default.
- W1996128058 cites W2010648161 @default.
- W1996128058 cites W2011082173 @default.
- W1996128058 cites W2013027047 @default.
- W1996128058 cites W2014634158 @default.
- W1996128058 cites W2015941944 @default.
- W1996128058 cites W2026468137 @default.
- W1996128058 cites W2027277921 @default.
- W1996128058 cites W2029499045 @default.
- W1996128058 cites W2033992055 @default.
- W1996128058 cites W2034402052 @default.
- W1996128058 cites W2036917525 @default.
- W1996128058 cites W2041637201 @default.
- W1996128058 cites W2046620531 @default.
- W1996128058 cites W2048623997 @default.
- W1996128058 cites W2049740824 @default.
- W1996128058 cites W2049808194 @default.
- W1996128058 cites W2055522356 @default.
- W1996128058 cites W2064431167 @default.
- W1996128058 cites W2064437160 @default.
- W1996128058 cites W2068639447 @default.
- W1996128058 cites W2074787353 @default.
- W1996128058 cites W2075745554 @default.
- W1996128058 cites W2079721061 @default.
- W1996128058 cites W2082137006 @default.
- W1996128058 cites W2083664211 @default.
- W1996128058 cites W2084560238 @default.
- W1996128058 cites W2085106134 @default.
- W1996128058 cites W2086030126 @default.
- W1996128058 cites W2087998194 @default.
- W1996128058 cites W2090676538 @default.
- W1996128058 cites W2091855459 @default.
- W1996128058 cites W2095256598 @default.
- W1996128058 cites W2099516923 @default.
- W1996128058 cites W2104049583 @default.
- W1996128058 cites W2106107076 @default.
- W1996128058 cites W2114885573 @default.
- W1996128058 cites W2122204548 @default.
- W1996128058 cites W2122756500 @default.
- W1996128058 cites W2123367066 @default.
- W1996128058 cites W2124812894 @default.
- W1996128058 cites W2125594832 @default.
- W1996128058 cites W2126722705 @default.
- W1996128058 cites W2126897233 @default.
- W1996128058 cites W2134686606 @default.
- W1996128058 cites W2135280067 @default.
- W1996128058 cites W2137227986 @default.
- W1996128058 cites W2139394184 @default.
- W1996128058 cites W2144147645 @default.
- W1996128058 cites W2144177716 @default.
- W1996128058 cites W2144191507 @default.
- W1996128058 cites W2144276100 @default.
- W1996128058 cites W2146321849 @default.
- W1996128058 cites W2147497390 @default.
- W1996128058 cites W2153142861 @default.
- W1996128058 cites W2153198333 @default.
- W1996128058 cites W2154694193 @default.
- W1996128058 cites W2155170237 @default.
- W1996128058 cites W2157440365 @default.
- W1996128058 cites W2162675860 @default.
- W1996128058 cites W2163665000 @default.
- W1996128058 cites W2164701887 @default.
- W1996128058 cites W2165214298 @default.