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- W1996132368 abstract "The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell–surface receptors. The synthesis and pharmacological results of 4-(indole-3-yl)quinazolines are described. The synthesized compounds are new high potent EGFR-tyrosine kinase inhibitors with excellent cytotoxic properties at different cell lines. Furthermore the 4-(indole-3-yl)quinazolines show some tendencies to inhibit the HER-2 TK, too. Moreover this substance class has remarkable strong fluorescence properties." @default.
- W1996132368 created "2016-06-24" @default.
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- W1996132368 date "2008-07-01" @default.
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- W1996132368 title "Syntheses of 4-(indole-3-yl)quinazolines – A new class of epidermal growth factor receptor tyrosine kinase inhibitors" @default.
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- W1996132368 doi "https://doi.org/10.1016/j.ejmech.2007.09.018" @default.
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