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- W1996132548 abstract "The effect of benzylpenicillin treatment was studied in mice infected intraperitoneally (i.p.) with endotoxin-liberating (E+) and non-liberating (E-) meningococci derived from the same original serogroup B strain. The E+ meningococci were significantly more virulent to mice than the E- variants in untreated animals (p less than 0.001). Large doses of benzylpenicillin given intravenously (i.v.) immediately after i.p. inoculation of E+ or E- meningococci resulted in complete, or almost complete survival. When treatment started later the number of surviving E- infected animals increased in all treatment regimens. By contrast, E+ infected animals had one or more treatment groups in all regimens that did not respond to benzylpenicillin at all. Benzylpenicillin treatment was given over a period of time as intermittent, regular i.v. doses, or as a depot preparation subcutaneously (s.c.). The mortality observed in E+ infected mice after benzylpenicillin i.v. was 75%, after benzylpenicillin procaine s.c. 82.5%, while animals receiving only saline i.v. had a mortality of 67.5%. The corresponding mortalities for E- infected animals were 15% (p = 0.0014), 42.5%, and 42.5%, respectively." @default.
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- W1996132548 date "1984-01-01" @default.
- W1996132548 modified "2023-10-16" @default.
- W1996132548 title "Effect of Benzylpenicillin in Mice Infected with Endotoxin-liberating or Non-liberating Variant Strains of Neisseria meningitidis" @default.
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- W1996132548 doi "https://doi.org/10.3109/00365548409070398" @default.
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