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- W1996132643 abstract "Abstract Aim Oral squamous cell carcinoma ( OSCC ) may be preceded by potentially malignant disorders such as leukoplakia and oral submucous fibrosis ( OSF ). p63 in concert with p53 regulates cell proliferation and differentiation and may have a role in potentially malignant and malignant lesions of the oral cavity. The aim of the study was to evaluate and compare the expression of p53 and p63 proteins in OSCC , leukoplakia, and OSF by immunohistochemistry ( IHC ). Methods Tissue sections of OSCC ( n = 20), leukoplakia ( n = 20), OSF ( n = 20) and normal oral mucosa ( n = 10) were stained with p53 and p63 antibodies by IHC . Mean labeling index ( LI ) among the study groups were compared using the Kruskal–Wallis test. Results The mean LI of p53 for OSCC , leukoplakia, OSF , and normal mucosa were 56.9 ± 21.3, 37.6 ± 12.6, 34.6 ± 8.7 and 15.1 ± 9, while mean LI of p63 were 56.8 ± 19.6, 42.3 ± 10.5, 32.8 ± 12.1, and 26.4 ± 9.4. The mean LI of p53 and p63 were significantly higher in OSCC , leukoplakia and OSF compared to normal mucosa ( P < 0.01; P < 0.01). Conclusion The significant increase in expression of p53 and p63 proteins in OSCC , leukoplakia, and OSF suggests their role as surrogate markers of malignant transformation." @default.
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- W1996132643 date "2013-06-18" @default.
- W1996132643 modified "2023-10-11" @default.
- W1996132643 title "Immunohistochemical detection of p53 and p63 in oral squamous cell carcinoma, oral leukoplakia, and oral submucous fibrosis" @default.
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- W1996132643 doi "https://doi.org/10.1111/jicd.12038" @default.
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